Predicting Responses to Exhausting, Prolonged, and Repeated Exercise Demands (PREPARED) for Heat

Launched by STATE UNIVERSITY OF NEW YORK AT BUFFALO · Jun 20, 2024

Keywords

ClinConnect Summary

The PREPARED clinical trial is studying how to improve performance during physically demanding tasks in hot conditions, like those faced by military personnel. The goal is to find a balance between completing missions more quickly and minimizing the risk of heat-related health issues and fatigue. By understanding how different work and rest cycles affect physical performance and heat strain, military leaders can make better decisions for training and operations in hot weather.

To participate in this study, individuals aged 18 to 45 who are healthy and physically active may be eligible. However, those with certain health conditions, such as heart or lung issues, or who are currently taking specific medications, might not qualify. Participants can expect to take part in exercise sessions while being monitored for their body's response to heat. It's important to know that some medical conditions or injuries may prevent participation, and for those who have difficulty with certain procedures, alternative options will be available.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy individuals
• • Physically active
• Exclusion Criteria:
• • History of cardiovascular, metabolic (such as clinical thyroid disease), respiratory, neural, or renal disease
• • Hypertensive (systolic blood pressure \> 139 mmHg, diastolic blood pressure \> 89 mmHg) or tachycardic (heart rate \> 100 bpm) during the screening visit
• • Taking medications or supplements known to effect physiologic responses to exercise or thermoregulation (e.g., beta blockers, omega-3 fatty acids, statins, aspirin)
• • Tobacco or nicotine use currently or in the past six months
• • Musculoskeletal injury expected to impact exercise in the protocol
• • A positive pregnancy test at any point in the study
• • Study physician discretion based on any other medical condition or medication
• • Inability to understand or follow instructions or the protocol
• • Gastrointestinal disease or previous surgery prohibiting core temperature capsule use. Participants with a contraindication can opt to insert the pill rectally as a suppository.