Artificial Saliva Containing Cumin and Ginger Extract in Hemodialysis Patients With Xerostomia

Launched by CHULALONGKORN UNIVERSITY · Jun 21, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how a special type of artificial saliva, which contains extracts from cumin and ginger, can help patients on hemodialysis who experience dry mouth, also known as xerostomia. The study will involve two groups of participants: one group will start using the artificial saliva for two weeks, take a break for two weeks, and then use a placebo (a version without the active ingredients) for another two weeks. The other group will do the opposite, starting with the placebo first. Researchers will measure things like how much saliva they produce, how dry their mouth feels, and their overall quality of life at different points during the study.

To be eligible for this trial, participants need to be at least 18 years old, have been on hemodialysis for more than three months, and have a very low saliva flow rate. However, some people cannot participate if they have certain medical conditions, are allergic to any of the ingredients in the study, or are currently pregnant or breastfeeding. If you choose to join the study, you can expect to provide feedback on your symptoms and receive close monitoring throughout the trial to see how well the artificial saliva works for you.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age more than 18 years
• • Hemodialysis patients with xerostomia (saliva flow rate less than 0.2 g/min)
• • Hemodialysed history more than 3 months
• • Be willing to participate in the study
• Exclusion Criteria:
• • Patients with sialolith or Sjogren's syndrome
• • Uncontrolled other diseases
• • Using artificial saliva for more than 2 weeks
• • Taking pilocarpine and cevimeline
• • Allergic to ginger, cumin, xylitol, and glycerin
• • Have mucositis
• • Pregnancy or lactation