Can the Origin of Sperm Affect Embryo Ploidy in Patients with Severe Male Factor Infertility?

Launched by GANIN FERTILITY CENTER · Jun 21, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how the source of sperm—whether it comes from a man's ejaculation or is collected directly from the testicles—might affect the quality of embryos in couples dealing with severe male infertility. The researchers want to compare the outcomes of a specific test called preimplantation genetic testing for aneuploidy (PGT-A), which checks for genetic abnormalities in embryos, to see if using different sperm sources leads to better results when transferring embryos that are genetically normal (euploid).

To participate in this study, men must be diagnosed with severe male infertility and have a female partner who is a normal responder to fertility treatments. The trial is currently recruiting participants and aims to gather valuable information that could help improve fertility treatments for couples facing these challenges. Participants can expect to undergo procedures related to in vitro fertilization (IVF) and may require testing to ensure they meet the eligibility criteria. It's important to note that certain conditions, like infections or previous uterine issues, may prevent some individuals from joining the trial.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Cases planned to have ICSI PGT-A cycles
• • Males diagnosed as severe male factor infertility
• • Normo responder female partners
• Exclusion Criteria:
• • Leukocytospermia
• • Presence of varicocele.
• • Known genetic abnormality
• • Use of sperm or oocyte donors
• • Use of gestational carrier
• • Presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection
• • Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation