The Influence of Chardonnay Marc Intake on Gut and Cardiometabolic Health

Launched by UNIVERSITY OF CALIFORNIA, DAVIS · Jun 25, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of consuming Chardonnay Marc powder, which is made from the skins and seeds of Chardonnay grapes, on gut health and heart-related issues in postmenopausal women. Researchers believe that adding this powder to the diet may help improve health markers related to cardiovascular diseases and metabolic conditions, thanks to its rich content of dietary flavanols, fiber, and other beneficial compounds.

To participate in this study, you need to be a postmenopausal woman aged between 45 and 70 years, with a body mass index (BMI) between 31 and 49.9, and have certain levels of fasting triglycerides in your blood. The trial is currently looking for volunteers, and participants will need to follow specific guidelines, including avoiding certain medications and dietary restrictions. If you qualify and choose to join, you will help researchers gather important information about how this dietary change might support better health outcomes.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Postmenopausal female, with a cessation of menses for at least 2 years
• • 45-70 years of age
• • BMI 25- 49.9 kg/m2
• • Fasting triglycerides \> 120 mg/dL
• • Subject is willing and able to comply with the study protocols and procedures.
• Exclusion Criteria:
• • Self-reported use of daily anticoagulation agents including aspirin, NSAIDs
• • Prescription medications and supplements, except for a 6 month stable dose of thyroid medications
• • Vegan, Vegetarians, food faddists or those consuming a non-traditional diet
• • Fruit consumption ≥ 3 cups/day
• • Vegetable consumption ≥ 4 cups/day
• • Coffee/tea ≥ 3 cups/day
• • Dark chocolate ≥ 3 oz/day
• • Self-reported restriction of physical activity due to a chronic health condition
• • Self-reported chronic/routine high intensity exercise
• • Blood pressure ≥ 140/90 mm Hg
• • Self-reported renal or liver disease
• • Self-reported heart disease, which includes cardiovascular events and stroke, diabetes
• • Peripheral artery disease Raynaud's syndrome or disease
• • Inability to properly place or wear the PAT probes or abnormal measurements on pre-screening PAT
• • Self-reported cancer within past 5 years
• • Self-reported gastrointestinal disorders, apart from appendix removal
• • Unwillingness to stop any supplement use, including herbal, plant or botanical, fish oil, oil supplements six weeks prior to study enrollment.
• • Indications of substance or alcohol abuse within the last 3 years
• • All forms of smoking (e.g. vaping, cigarette, cannabis)
• • Current enrollee in a clinical research study.