Understanding Beta Cell Disorders Through the Study of Rare Genotypes (ENDURE)
Launched by UNIVERSITY OF EXETER · Jun 21, 2024
Trial Information
Current as of July 25, 2025
Recruiting
Keywords
ClinConnect Summary
The ENDURE trial is focused on understanding specific problems with beta cells, which are the cells in the pancreas that produce insulin. This study aims to learn more about how certain rare genetic changes can affect these cells and lead to conditions like diabetes and hyperinsulinism. Researchers want to gather information from both individuals with these genetic changes (the cases) and those without them (the controls) to compare their results. By doing this, they hope to identify specific markers in the blood and understand how these genetic changes impact the body's function.
To participate, individuals need to be between 21 and 36 years old and able to give informed consent. Those with a genetic variant causing a beta cell disorder can join as cases, while those without the variant can join as controls, matched by age and body weight. Participants will attend a study visit where they will provide blood samples and have their height and weight measured. An optional MRI scan may also be performed, depending on their genetic background. Importantly, there is no treatment involved in this study, and participants’ regular healthcare will continue as normal.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria
- • Mental capacity to give informed consent
- • Of any sex, ethnicity, location.
- • Group 1: Cases will have a genetic variant(s) resulting in a beta cell disorder.
- • Group 2: Controls will not have a genetic variant(s) resulting in a beta cell disorder and will be matched to a Case for sex, age (+/- 15%) and BMI (+/- 3 kg/m2).
- • Exclusion Criteria
- • Lack of mental capacity to give informed consent
- • Age \<6 years; \>99 years
- Additional exclusions for MRI assessments:
- • Cochlear Implant
- • Aneurysm Clips
- • Neurological stimulator
- • Implanted cardiac devices (ICD, PPM, loop recorders, or any others)
- • Metal heart valve
- • History of metal foreign bodies in orbits
- • Other implanted metal device which prevents MRI
- • Known claustrophobia.
About University Of Exeter
The University of Exeter is a leading research institution in the United Kingdom, renowned for its commitment to advancing knowledge and innovation across various disciplines, including health and medicine. As a clinical trial sponsor, the university leverages its extensive academic expertise and state-of-the-art facilities to conduct rigorous and ethically sound research. The University of Exeter aims to translate scientific findings into practical applications that improve patient outcomes and inform public health strategies, fostering collaboration between researchers, healthcare professionals, and community stakeholders to address critical health challenges.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Exeter, Devon, United Kingdom
Patients applied
Trial Officials
Andrew Hattersley, FRS, FMed
Principal Investigator
University of Exeter
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported