The Effect of Piracetam on Diabetic Peripheral Neuropathy Patients

Launched by AIN SHAMS UNIVERSITY · Jun 23, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the effects of a medication called Piracetam on patients with diabetic peripheral neuropathy, a condition that causes pain and discomfort in the legs and feet due to nerve damage from diabetes. The goal is to see if Piracetam can improve nerve function and help ease the symptoms of diabetic neuropathy, which affects many people with diabetes and can significantly impact their quality of life.

To participate in this study, you must be an adult over 18 years old, have been diagnosed with type 2 diabetes, and be on insulin therapy for at least three months. It’s important that your diabetes is managed well, with a blood sugar level (measured by HbA1C) above 7.5%. However, there are several reasons you might not be eligible, such as having certain other health conditions or taking specific medications. If you qualify and choose to join, you will be monitored for the safety and effectiveness of the treatment. This trial is currently not yet recruiting participants, so it may take time before it begins.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Adults (\>the age of 18).
• • 2. Established diagnosis of type 2 Diabetes Mellitus.
• • 3. Patients receiving insulin therapy.
• • 4. Stable regimen for at least 3 months prior to inclusion in the study
• • 5. HbA1C\>7.5%
• Exclusion Criteria:
• • Patients with inadequate hepatic function Alanine aminotransferase, Aspartate aminotransferase (ALT, AST \> or equal to 3 times upper normal limit).
• • Patients with myopathy, epilepsy, malignancy, unstable psychiatric illness, bleeding tendency, or peripheral vascular diseases.
• • Patients with an estimated Glomerular Filtration Rate (GFR) Less than 45 ml/min and albumin/creatinine ratio or urea to creatinine \>30.
• • Patients with any conditions that could confound pain assessment (for ex: other severe pain or skin conditions in the area affected by neuropathy.
• • Cognitive or language difficulties that would impair understanding/completion of the assessment instruments.
• • Presence of foot ulcers.
• • Causes of neuropathy other than diabetes and significant neurological diseases.
• • Pregnant and/or breastfeeding women.
• • Use anticonvulsants, antidepressants, membrane stabilizers, and opioids.
• • Patients with a history of Substance use and alcohol abuse,
• • Patients with a history of (cerebral hemorrhage) or at risk of blood diseases.
• • Patients allergic to piracetam