Modeling Host-Pathogen Interaction Using Lymphoid Organoids

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Jun 27, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how a type of bacteria called Staphylococcus aureus (S. aureus) interacts with the body, particularly when it causes infections in the spine. These infections can be very serious, leading to complications like paralysis. Researchers want to understand this interaction better so they can find more effective treatments for S. aureus infections. To do this, they will use tissue samples from the tonsils of people who are having their tonsils removed, which is a common surgery.

To be eligible for the study, participants must be at least 2 years old and scheduled for a tonsillectomy. They should not have any active infections or certain medical conditions that could put them at risk. Participants will answer some questions about their health and will collect a nasal swab before their surgery. After the surgery, the surgeon will send the tonsil tissue and nasal swab to the researchers. This study is important because it may help improve how we treat serious infections caused by S. aureus in the future.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• To be eligible to participate in this study, an individual must meet all of the following criteria:
• • Aged \>=2 years.
• • Undergoing tonsillectomy as part of their clinical care.
• • Able to provide informed consent (for ages \>=18 years) or has a parent or guardian who can provide informed consent on their behalf (for ages \<18 years).
• • Willing to allow samples and data to be stored and shared for future secondary research.
• • Willing to allow future genetic testing on their biospecimens.
• EXCLUSION CRITERIA:
• An individual who meets any of the following criteria will be excluded from participation in this study:
• • Active infection.
• • Active tonsilitis.
• • Pregnant.
• • Diagnosed with an immunosuppressive condition or currently taking immunosuppressive medications.
• • Current or past intravenous drug use.
• • Any condition that, in the judgment of the investigator, may put the participant at undue risk or make them unsuitable for participation in the study