Possible Action of Resveratrol in Improving the Outcomes of IVF/ICSI in Couples With Unexplained Infertility

Launched by ANDROS DAY SURGERY CLINIC · Jun 27, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating whether a supplement called resveratrol can improve outcomes for couples facing unexplained infertility during assisted reproductive techniques like IVF (in vitro fertilization) or ICSI (intracytoplasmic sperm injection). The researchers believe that resveratrol may help enhance the development of eggs in women, which could lead to better chances of pregnancy. This study is particularly important because it focuses on a group of couples whose infertility causes are not clearly understood, and previous research on resveratrol in this context is limited.

To participate in this trial, women aged 18 to 40 with a healthy weight and regular menstrual cycles are eligible, provided they have been trying to conceive for at least 18 months without success. Participants must also meet certain criteria regarding their partner’s health and fertility. During the trial, participants will be randomly assigned to receive either the resveratrol supplement or a placebo (a non-active treatment), and their progress will be closely monitored. The goal is to see if taking resveratrol leads to better egg development and overall outcomes in IVF/ICSI treatments.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Female age 18-40 years
• • Female BMI 18-30 kg/m2
• • normal menstrual cycles (26-35 days)
• • duration of infertility at least 18 months
• • normal semen parameters as established by WHO laboratory manual for the examination and processing of human semen Sixth edition
• • normal US evaluation of male genital anatomy
• • normal FSH, LH, Prolactin, Total Testosterone, Estradiol in male partner
• • bilateral tubal patency established by 3-D HyFoSy or HSG
• • normal uterine cavity evaluated by 3-D HyFoSy or HSG or hysteroscopy
• • absence of antibodies Anti-Chlamyidia Trachomatis IgG/IgM
• • failed intrauterine inseminations or couple's decision to refuse intrauterine inseminations
• Exclusion Criteria:
• • ≥15 cigarettes per day at least in one of the partners
• • irregular menstrual cycles
• • poor ovarian response (on the basis of the "Bologna" Criteria)
• • inaccessible ovaries
• • severe endometriosis (stage III-IV of the ASRM revised classification)
• • significant systemic diseases
• • heterologous fertilization
• • previous pelvic surgery
• • presence of ovarian cysts
• • polycystic ovary syndrome
• • use of hormonal contraception in the previous 3 months
• • use of gonadotrophins in the previous 3 months
• • III stage varicocele