Diagnostic of D-lactate in Cerebrospinal Fluid Level in Patients With Suspected Ventriculostomy-related Meningitis

Launched by UNIVERSITY HOSPITAL, TOULOUSE · Jun 25, 2024

Keywords

ClinConnect Summary

The TOTEM study is a clinical trial aimed at finding out how effective a specific test, called the D-lactate assay, is in diagnosing a type of brain infection known as ventriculostomy-related meningitis. This study will take place at the Toulouse University Hospital, specifically in the neurosurgical intensive care unit, and it will involve patients who are suspected of having this infection after having a device called an external ventriculostomy placed in their brain. The researchers want to see if measuring D-lactate levels in the fluid around the brain can help identify this infection more accurately.

To participate in the study, individuals must be at least 18 years old and have had an external ventriculostomy placed at the hospital. They should also show signs of a brain infection, such as fever, headache, or changes in their mental state. It’s important to note that some people won’t be able to join the study, including those who have had certain types of infections recently or specific medical conditions. If eligible, participants will give their consent to take part and can expect to have their cerebrospinal fluid tested for D-lactate levels to help doctors understand their condition better. This study is not yet recruiting participants, so more information will be available as it progresses.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ⩾ 18 years.
• • Patient with an external ventriculostomy implanted at the Toulouse University Hospital.
• • Patient suspected of nosocomial meningitis due to a febrile syndrome (in the absence of any other identified infectious site), headache, nausea, lethargy, change in neurological status, meningeal syndrome, epileptic event and cutaneous or subcutaneous inflammation at the ventriculostomy site of insertion.
• • Patient having expressed oral consent, after free and informed information.
• • Patient affiliated to a social security scheme.
• Exclusion Criteria:
• • Diagnosis of community meningitis.
• • Proven or suspected meningitis and/or ventriculitis during the previous month.
• • Diagnosis of nosocomial meningitis made in another medical centre prior to admission.
• • Short bowel syndrome.
• • Acute mesenteric ischaemia.
• • End-stage renal failure (GFR \< 15 ml/min/m2).
• • Peritoneal dialysis.
• • Patient participating in another research protocol with an exclusion period still in progress.
• • Pregnant or breastfeeding woman.
• • Patient under guardianship or trusteeship, persons placed under the protection of justice