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Search / Trial NCT06483529

Respiratory Mechanics Measurement of Ventilated Patients Through Low-frequency Oscillometry Technique

Launched by UNIVERSITAIR ZIEKENHUIS BRUSSEL · Jul 1, 2024

Trial Information

Current as of July 26, 2025

Recruiting

Keywords

Oscillometry Intensive Care Unit Intubated Patients Compliance Resistance Impedance

ClinConnect Summary

This clinical trial is studying a new method called respiratory oscillometry (RO) to measure how well the lungs are working in patients who are on a ventilator. This technique uses small pressure waves to gather information about lung function, which can help doctors understand how to better treat patients with respiratory failure, especially those who were affected during the COVID-19 pandemic. The trial aims to compare the RO method with current standard techniques for measuring lung function to see how well they work together.

To participate in this study, participants need to be between 18 and 84 years old, currently intubated (having a tube placed in their windpipe to help them breathe), and have been stable for at least 48 hours without major changes in their treatment. Patients will be closely monitored during the trial, and the RO measurements will be done using a special ventilator that can safely switch back to regular breathing support at any time. This research is important as it may lead to improved ways of managing patients with serious breathing issues in the future.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • intubation
  • Controlled ventilation with an intention to continue controlled ventilation for the following 4 hours.
  • Richmond agitation sedation scale of -4 or less
  • Hemodynamically stable patient with either
  • unchanged vasopressor dose administration for at least 60 minutes before the start of the measurements
  • no vasopressor need and no vasopressor initiated within 60 minutes of measurements
  • No planned intervention in the coming 2 hours
  • Survival for at least 48 hours
  • Protective ventilation (inspired oxygen concentration≤60%, plateau pressure ≤30 cmH2O , driving pressure≤ 15cmH2O)
  • PEEP (Positive End Expiratory Pressure) ≤10
  • Exclusion Criteria:
  • assist ventilation
  • Ventilator asynchronies
  • Intermittent spontaneous breathing
  • nitric oxide therapy
  • presence of an extra corporeal membrane oxygenation device
  • Ventilation is not possible within the lower and upper inflection point of the low flow pressure volume curve.
  • Unstable right heart failure
  • Unstable lung embolism
  • Standard of care without Sedline® or invasive arterial catheter
  • Do not reanimate code of 2, 3 or 4
  • Subjects who are healthy, minors, pregnant women, patients in emergency situation
  • Outside the age range 18 to 84 years

About Universitair Ziekenhuis Brussel

Universitair Ziekenhuis Brussel (UZ Brussel) is a leading academic medical center in Belgium, renowned for its commitment to advancing healthcare through innovative research and clinical trials. As a prominent institution affiliated with the Vrije Universiteit Brussel, UZ Brussel integrates cutting-edge medical research with high-quality patient care. The hospital's multidisciplinary teams are dedicated to exploring novel therapeutic approaches and contributing to the development of evidence-based treatments, ensuring the highest standards of safety and efficacy in clinical research. With a strong focus on collaboration and knowledge dissemination, UZ Brussel plays a pivotal role in shaping the future of medicine and improving patient outcomes.

Locations

Jette, Brussel Hoofstedelijk Gewest, Belgium

Patients applied

0 patients applied

Trial Officials

joop jonckheer, MD, PhD

Principal Investigator

Universitair Ziekenhuis Brussel

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported