Efficacy and Safety of HB-1 for Panic Disorder

Launched by HONEYBRAINS BIOTECH LLC · Jun 26, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called HB-1 for individuals with Panic Disorder, which is a mental health condition that causes sudden and intense feelings of fear and anxiety. The trial aims to see how safe and effective HB-1 is compared to a placebo (a non-active treatment) and two other medications. The researchers are looking for adult men and women between the ages of 18 and 65 who have experienced at least one unexpected panic attack in the week before joining the study. Participants must be stable on their current medications for at least three months and be willing to continue those medications throughout the trial.

If you decide to participate, you will take either HB-1, one of the other medications, or a placebo for a certain period. You'll also need to attend regular visits and complete some assessments during the trial. It's important to know that there are specific requirements for joining, such as not having certain other mental health conditions or severe medical issues. Additionally, women who can become pregnant will need to follow specific birth control guidelines during the study. This trial is currently recruiting participants, so if you or someone you know has Panic Disorder and is interested, it could be a good opportunity to potentially help find a new treatment option.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female aged 18 to 65 years old, inclusive, at the time of informed consent.
• • 2. Meets Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-V) Criteria for Panic Disorder.
• • 3. Minimum of one full, unexpected panic attack in week prior to screening (via Diagnostic and Statistical Manual of Mental Disorders 5th edition \[DSM-V\] based structured interview).
• • 4. Medically stable on current medication regimen for at least 3 months (including as needed \[PRN\] medications), as determined by Investigator.
• • 5. Willing to remain on current doses of other psychiatric medications throughout the length of the trial.
• • 6. Willing and able to safely stop / avoid any of the following prior to study trial: Inhibitors or inducers of CYP3A4 (grapefruit juice, erythromycin, ritonavir, telithromycin, rifampin), HMG-CoA Reductase Inhibitors (Simvastatin, Lovastatin, Atorvastatin), Beta Blockers (Timolol eyedrops, Metoprolol), Neuromuscular Blocking Agents (curare-like and depolarizing), Antihypertensive Agents (Prazosin and vasodilators, angiotensin-converting enzyme inhibitors, diuretics, beta blockers), Inhalation Anesthetics, Disopyramide, Flecainide, Quinidine, Cimetidine, Lithium, Carbamazepine, Phenobarbital, Cyclosporine, Digitalis, Aliskiren, Ramipril and Ramiprilat, aspirin, propranolol.
• • 7. Willing and able to safely stop / avoid sensitive P-glycoprotein inhibitors.
• • 8. Willing to take HB-1, telmisartan, verapamil, or placebo.
• • 9. Willing and able to provide informed consent indicating an understanding of the requirements of the study and a willingness to comply with scheduled visits and all study procedures.
• • 10. Female subjects must be surgically sterile (or have a monogamous partner who is surgically sterile) or be at least 2 years postmenopausal or commit to use 2 acceptable forms of birth control (defined as the use of an intrauterine device, a barrier method with spermicide, condoms, any form of hormonal contraceptives, or abstinence) for the duration of the study and for 4 months following the last dose of study treatment. Male subjects must be sterile (biologically or surgically) or commit to the use of a reliable method of birth control (condoms ± spermicide) for the duration of the study and for 4 months following the last dose of study treatment. Individuals who are involved exclusively in same-sex relationships are exempt from the birth control requirements but must agree to abide by the recommendations if they do engage in a heterosexual relationship.
• • 11. Female subjects who are women of childbearing potential (WOCBP) must have a negative pregnancy test at Screening, within 7 days of dosing with study treatment.
• Exclusion Criteria:
• • 1. Any concomitant disease, condition, or treatment that could interfere with the conduct of the study, or that would, in the opinion of the Investigator or Sponsor, pose an unacceptable risk to the participant in the study or interfere with the interpretation of study data.
• • 2. Concurrent treatment with benzodiazepines (e.g. alprazolam, diazepam, clonazepam, lorazepam) as assessed by clinical interview and urine toxicology testing.
• • 3. Severe Agoraphobia (Panic Disorder Symptom Severity Scale (PDSS) Item 4 "agoraphobic fear/avoidance" \> 2).
• • 4. Severe Generalized Anxiety (Hamilton Anxiety Rating Scale \[HAM-A\] Total Score \> 23).
• • 5. Prior lifetime history of suicide attempt, Columbia Suicide Severity Rating Scale (C-SSRS) ≥ 4 in the past 6 months or prior lifetime history of hospitalization for depression.
• • 6. Diagnosis of Substance Use Disorder, Obsessive-Compulsive Disorder (OCD), Bipolar I, Bipolar II disorder or schizoaffective or other psychotic disorders (per Structure Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders 5th Edition (DSM-V) \[SCID-V\].
• • 7. Severe uncontrolled cardiac disease within 6 months of Screening, including but not limited to uncontrolled hypertension, hypotension (defined as below 90/60); unstable angina; myocardial infarction (MI) or cerebrovascular accident (CVA).
• • 8. Any clinically significant electrocardiogram (ECG) abnormalities at screening.
• • 9. Inadequate hepatic function defined as total bilirubin \> 1.5 × the upper limit of normal (ULN) ranges of each institution, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \> 3 × the ULN range of each institution.
• • 10. Inadequate renal function defined as serum creatinine \> 1.5 × the upper limit of normal (ULN) range of each institution and/or estimated glomerular filtration rate (eGFR) \< 60.
• • 11. Any clinically significant abnormalities in clinical laboratory assessments as assessed by the Investigator.
• • 12. Any other systemic conditions or organ abnormalities that in the opinion of the Investigator may interfere with the conduct and/or interpretation of the current study.
• • 13. Unable to complete neuropsychological testing.
• • 14. Already on treatment with either telmisartan or verapamil or both.
• • 15. Has a history of hypersensitivity or severe allergic reaction to either telmisartan or verapamil, or any component of either licensed drug.
• • 16. Documented contraindication to taking telmisartan or verapamil: (e.g., Duchenne's muscular dystrophy, myasthenia gravis).
• • 17. Pregnant or breastfeeding.
• • 18. Participation in another current clinical trial or prior trial within the last three months.
• • 19. Urinalysis evidence of exposure to substances that may interfere with HB-1 testing (per investigator discretion).