Investigating Multimodally Endothelial Dysfunction in Ocular and Systemic Disease

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Jun 26, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how the blood vessels in the eye are affected in patients who have certain health conditions, such as kidney diseases, heart failure, small vessel disease, and glaucoma. The goal is to understand how these conditions may be linked and how they impact the health of blood vessels in the eye. Researchers are currently recruiting participants for this study, which is open to adults aged 65 and older, and anyone, regardless of gender, who meets the necessary health criteria.

To be eligible for this trial, participants must have one or more of the following: a diagnosis or suspicion of glaucoma, chronic kidney disease, heart failure with symptoms, or small vessel disease identified through brain imaging. People without any relevant medical history may also join. Participants will be asked to provide consent and will undergo evaluations related to their eye and overall health. This trial aims to provide valuable insights into the connections between these diseases, which could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult patients with a confirmed or suspect diagnosis of glaucoma based on intra-ocular eye pressure, visual field defect and structural optic nerve changes, regardless their age.
• • Adult patients with chronic kidney disease regardless their age.
• • Adult patients with heart failure with preserved ejection fraction (HFpEF), regardless their age: symptomatic heart failure with Left Ventricle Ejection Fraction \> 50% AND BNP \> 35 pg/ml (or NT-proBNP\>125 pg/ml) OR signs of diastolic dysfunction according to the European Society of Cardiology guidelines 2016
• • Adult patients with confirmed small vessel disease as is diagnosed on routine neurological imaging, regardless their age.
• • People without history or track record of any relevant pathology, including cardiovascular and renal diseases, regardless their age
• • Capable and willing to participate (informed consent)
• Exclusion Criteria:
• • Diabetes
• • Personal medical history of retinal neovascularization.
• • Unable or unwilling to give consent