Evaluation of Axillary Lymph Node Metastasis Status of Breast Cancer Based on Pathological Images and Virtual Staining

Launched by YUNNAN CANCER HOSPITAL · Jun 26, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new technology that uses artificial intelligence (AI) to create stained images from unstained tissue samples of lymph nodes in breast cancer patients. The researchers want to see if this AI model can make images that are good enough for doctors to use in their diagnoses. They will look at samples from both paraffin-embedded lymph nodes (which are preserved in wax) and frozen sentinel lymph nodes (the first nodes that cancer might spread to) taken from breast cancer patients.

To be eligible for this trial, participants need to be female patients aged 18 to 75 who have been diagnosed with breast cancer and are undergoing surgery for their cancer. They should have clear results from their lymph node samples after surgery. The trial is not currently recruiting participants, but it aims to help improve how lymph node evaluations are performed, which could lead to better treatment decisions for breast cancer patients in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• Part 1:
• • Female patients aged 18-75 with breast cancer; Undergoing surgical excision of breast cancer and sentinel lymph node biopsy/axillary lymph node dissection; Lymph nodes with clear postoperative paraffin pathological results.
• Part 2:
• • Patients aged 18-75 with one of the following cancers: thyroid, lung, esophagus, stomach, colorectal, prostate, bladder, or cervix; Undergoing surgical resection of lymph nodes; Lymph nodes with clear postoperative paraffin pathological results.
• Part 3:
• • Female patients aged 18-75 with breast cancer; Undergoing surgical excision of breast cancer and sentinel lymph node biopsy; Sentinel lymph nodes with clear postoperative paraffin pathological results.
• Exclusion Criteria:
• Part 1 / Part 2:
• • Lymph node diagnosis is missing; Absence of lymph node component in the slice.
• Part 3:
• • Sentinel lymph node diagnosis is missing; Absence of lymph node component in the frozen slice.