Second Line Endovascular Treatment in Acute DVT

Launched by RUSH UNIVERSITY MEDICAL CENTER · Jun 26, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Second Line Endovascular Treatment in Acute DVT," is investigating new treatment options for patients with deep vein thrombosis (DVT) who have not improved after a week of standard blood-thinning medications. The study aims to determine whether additional procedures, specifically catheter-directed thrombolysis (a method to break up blood clots using medication) and mechanical thrombectomy (a procedure to remove clots), can be safe and effective for these patients. Participants will be closely monitored with follow-up tests to see how well these treatments work compared to those who only receive the usual care.

To be eligible for the trial, participants must be at least 18 years old, have a recent diagnosis of a specific type of DVT in the leg, and be suitable for blood-thinning treatment. However, patients under 18, those over 75, or anyone with certain medical conditions or risks may not qualify. If you join the study, you will be randomly assigned to either receive the additional treatments or continue with standard care. This research is important because it could lead to better options for patients who need more help with their DVT treatment. The trial is not yet open for enrollment, so keep an eye out for updates if you or a loved one may be interested.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients over 18 years of age
• • Patients who have diagnosis of acute femoropopliteal acute deep venous thrombus
• • Patients eligible for anticoagulation treatment
• Exclusion Criteria:
• • Patients under 18 years of age
• • Patients over 75 years of age
• • Symptoms starting date of more than 14 days
• • Patients who have contraindication for anticoagulation treatment
• * Patients who have high bleeding risk (more than 2 of the following risk factors):
• • Age \>65 years
• • Previous bleeding
• • Cancer
• • Metastatic cancer
• • Renal failure
• • Liver failure
• • Thrombocytopenia
• • Previous stroke
• • Diabetes
• • Anemia
• • Antiplatelet therapy
• • Poor anticoagulant control
• • Comorbidity and reduced functional capacity
• • Recent surgery in 30 days
• • Frequent falls
• • Hemodynamically unstable patients
• • Patients having severe swelling and pain, cyanosis, and absent pulses consistent with compartment syndrome.