The Validity of Urinary Titin and Skeletal Muscle Index as Predictor of Muscle Weakness in Critically Ill Patients. A Prospective Cohort Study

Launched by ZAGAZIG UNIVERSITY · Jun 27, 2024

Keywords

ClinConnect Summary

All patients will be subjected to the following:

Informed consent will be obtained from patients. History taking including age, sex, comorbidities, current medications, ethnicity, reason for admission, and body mass index (BMI). General clinical examination. General laboratory investigations: (CBC, Random blood sugar, CRP, ESR).

Urinary Titin Measurement:

The first urine sample will be collected using a urethral catheter within 12 h of ICU admission and 24-hour urine samples d 24-hour urine samples on days 2, 3, 5, and 7.

Urinary titin will be measured using an ELISA kit (Maruyama et al...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Consent from relatives of first degree. Consecutive adult patients who will be expected to remain in ICU for \>5 days will be enrolled. Nonsurgical critically ill patients will be included because surgical insult reportedly increased urinary titin level (Tanihata et al., 2019). Age more than 18 years. Both male and female.
• Exclusion Criteria:
• • Surgery not including percutaneous abscess drainage. Patients with expected prehospital functional status of \<48 hours. Chest tube insertion, and tracheostomy in ICU. 8 Current pregnancy. Diagnosis of primary neuromuscular disease. Trauma at the measurement point.