Preoperative Use of Pantoprazole for Prevention of Post Operative Nausea and Vomiting in Gynecologic Surgery

Launched by UNITED STATES NAVAL MEDICAL CENTER, PORTSMOUTH · Jun 28, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether a medication called pantoprazole can help prevent nausea and vomiting after gynecologic surgery in women aged 18 to 79. Pantoprazole is commonly used to treat acid reflux and heartburn. In this trial, some participants will receive pantoprazole, while others will receive a placebo (a pill that looks like the medication but has no active ingredients) to see if pantoprazole makes a difference in reducing postoperative nausea and vomiting.

To participate, women must be undergoing elective gynecological surgery that requires general anesthesia, but they should not be pregnant, have certain gastrointestinal issues, or have a history of specific stomach treatments within the last month. Participants will take three pills around the time of their surgery: two before the operation and one the night after. The trial is currently recruiting, and it's an opportunity for women who may be at risk for nausea and vomiting after surgery to potentially benefit from this treatment.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Undergoing elective gynecological surgery by either an open abdominal or minimally invasive approach (to include both endoscopic and vaginal). Procedure must be performed under general anesthesia.
• Exclusion Criteria:
• • Pregnant,
• • Patients with gastrointestinal disease requiring ongoing medical management.
• • Prior gastrointestinal surgery with the exception of diagnostic procedures, appendectomy and cholecystectomy.
• • Patients with a history of H2 receptor blocker use, proton pump inhibitor use or other GERD specific therapy within 30 days of surgery.
• • Any patient identified by their surgical care team as having a history of PONV warranting additional perioperative prophylaxis.
• • Known r suspected malignancy
• • Lactose intolerance