Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial

Launched by WAKE FOREST UNIVERSITY HEALTH SCIENCES · Jun 28, 2024

Keywords

ClinConnect Summary

The Emergency Medicine Cardiovascular Risk Assessment for Lipid Disorders Trial, also known as EMERALD, is studying a new way to help patients in the emergency department who are at risk for heart problems. Specifically, it aims to see if a special program can effectively lower unhealthy cholesterol levels in patients who are being evaluated for conditions like chest pain or heart attacks but are not already receiving proper heart care outside the hospital. The trial will also look at how well patients follow the program and what factors influence its success.

To be eligible for this trial, participants must be between the ages of 40 and 75, have a high risk of heart disease, or have diabetes. They should be dealing with heart-related issues but not currently taking cholesterol-lowering medications. If someone joins the study, they can expect to receive personalized care aimed at improving their heart health and will be asked to come back for follow-up appointments to track their progress. It’s important to note that certain patients, like those with severe health issues or who are pregnant, will not be able to participate.

Gender

ALL

Eligibility criteria

• • Inclusion Criteria
• • 1. Evaluation for Acute Coronary Syndrome
• • 2. Age 40-75 Years
• • 3. 10-year Atherosclerotic Cardiovascular Disease (ASCVD) Risk ≥7.5% or Known Diabetes or
• Known ASCVD:
• • 1. Myocardial Infarction
• • 2. Unstable Angina
• • 3. Percutaneous Coronary Intervention
• • 4. Coronary Artery Bypass Graft
• • 5. Stroke
• • 6. Transient Ischemic Attack
• • 7. Peripheral Artery Disease
• • Exclusion Criteria
• • 1. ST-Segment Elevation Myocardial Infarction (STEMI) Activation
• • 2. ST Depression \>1 mm in Contiguous Leads
• • 3. On a Lipid Lowering Agent (Statin, PCSK9 Inhibitor, Bempedoic Acid, Ezetimibe, Inclisiran, etc.)
• • 4. Inability to Return for 30-day Follow-up
• • 5. Unstable Vitals (Systolic blood pressure \<90, HR \>120 or \<50, oxygen saturation \<90%)
• • 6. Statin Intolerance
• • 7. Any Resulted High-Sensitivity Troponin I ≥100 ng/L
• • 8. End-stage renal disease (ESRD) and/or glomerular filtration rate (GFR) \<30 mL/min/1.73 m2
• • 9. Liver Cirrhosis
• • 10. Pregnancy
• • 11. Anticipated Hospitalization
• • 12. Life Expectancy \<1 Year
• • 13. Transfer from Another Hospital
• • 14. Prisoner
• • 15. Non-English Speaking