The Effect of Cold Therapy on Peripheral Neuropathy

Launched by KOÇ UNIVERSITY · Jun 28, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how cold therapy can help reduce symptoms of peripheral neuropathy in children with cancer who are receiving a specific chemotherapy drug called vincristine. Peripheral neuropathy can cause uncomfortable symptoms like numbness, tingling, and pain in the hands and feet, which can make daily life difficult for these young patients. The goal of the study is to see if using cold therapy can improve these symptoms and enhance the quality of life for children undergoing treatment.

To participate in the trial, children must be between the ages of 7 and 18, currently receiving vincristine therapy, and diagnosed with specific types of cancer such as leukemia or Wilms tumor. They also need to be able to speak and understand Turkish. Not everyone can join; for instance, children with certain medical conditions or those receiving other treatments that could interfere with cold therapy will be excluded. Participants will receive cold therapy during the trial, and researchers will monitor its effects on their symptoms and overall well-being. This study is important because it aims to provide new insights and evidence for improving care for children facing these challenging side effects of cancer treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • aged 7-18 years,
• • receiving VCR therapy,
• • diagnosed with leukemia, medulloblastoma, rhabdomyosarcoma, or Wilms tumor,
• • able to speak and understand Turkish
• • receiving initial treatment
• • consent to participate in the research project.
• Exclusion Criteria: Risk factors for peripheral neuropathy were considered exclusion criteria. Risk factor criteria were:
• • receiving a dose of VCR \<2.5 mg/m2,
• • receiving VCR and azole antifungal treatment simultaneously,
• • a hematological malignancy with neurological disease,
• • a history of peripheral neuropathy,
• • diabetes,
• • self-reported cold sensitivity.
• • Additionally, children who receive chemotherapy or other treatment using the peripheral veins of their hands or feet will not be included since the cold application is contraindicated.