Role of Inflammation in Vascular Phenotype Associated with E-cigarette Use

Launched by UNIVERSITY OF IOWA · Jun 28, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how e-cigarette use, also known as vaping, affects blood vessel health, particularly focusing on inflammation and a condition called endothelial dysfunction. Endothelial dysfunction can increase the risk of heart disease, which is a major health concern, especially for those who smoke or use e-cigarettes. The study aims to understand the specific role that inflammation plays in these changes, particularly among young adults aged 18 to 24.

To participate in the trial, individuals must be between 18 and 24 years old. They can either be current e-cigarette users with at least six months of experience or have never used e-cigarettes at all. However, those with a history of tobacco cigarette use, certain health conditions, or those taking specific medications are not eligible to join. Participants in the study can expect to undergo tests that will help researchers learn more about the effects of vaping on their blood vessel function. This study is important because it seeks to fill gaps in our understanding of the health impacts of e-cigarettes, especially for young people who are increasingly using these devices.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 - 24 years of age
• • no history of e-cigarette use (control) OR current with 6 months or more history of e-cigarette use (chronic use).
• Exclusion Criteria:
• • tobacco cigarette use (current or history of)
• • use of stimulant drugs
• • skin diseases
• • cardiovascular disease
• • diagnosed or suspected hepatic or metabolic disease including diabetes
• • statin or other cholesterol-lowering medication
• • antihypertensive medication
• • current pregnancy or breastfeeding
• • blood pressure greater than or equal to 140mmHg systolic and/or greater than or equal to 90mmHg diastolic
• • allergy to materials used during the experiment
• • known allergies to salsalate or other study drugs