Neural Computations of Goal-directed Decision-making
Launched by CEDARS-SINAI MEDICAL CENTER · Jun 28, 2024
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Flexible goal-directed decision-making is a core aspect of higher-order adaptive biological intelligence. A number of psychiatric disorders involve impairments in goal-directed decision-making, yet the current lack of even a basic understanding of how goal-directed action selection is implemented at the neuronal level in humans hinders the ability to pinpoint these neuropsychiatric dysfunctions. In particular, it is completely unknown how goals, and the stimuli and actions that need to be selected from in order to pursue them, are represented at the level of single neurons, nor how goals ge...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Intractable epilepsy, undergoing invasive monitoring
- • Age ≥13
- • Full Scale Intelligence Quotient \> 70
- • Ability to comprehend and perform simple behavioral tasks by pressing buttons on laptop computer in response to questions
- Exclusion Criteria:
- • Determination by clinicians and investigators that a patient is unable to complete the behavioral tasks required for the protocol due to either cognitive limits, psychological limits, or pain
About Cedars Sinai Medical Center
Cedars-Sinai Medical Center is a renowned nonprofit academic medical center located in Los Angeles, California, recognized for its commitment to patient care, research, and education. As a leading institution in clinical trials, Cedars-Sinai harnesses innovative approaches to advance medical knowledge and improve treatment outcomes across various specialties. With a multidisciplinary team of experts, state-of-the-art facilities, and a patient-centered approach, Cedars-Sinai actively contributes to the development of novel therapies and interventions, ensuring the highest standards of clinical research while prioritizing patient safety and ethical considerations.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Los Angeles, California, United States
Patients applied
Trial Officials
Ueli Rutishauser, PhD
Principal Investigator
Cedars-Sinai Medical Center
Adam Mamelak, MD
Principal Investigator
Cedars-Sinai Medical Center
John O'Doherty, PhD
Principal Investigator
California Institute of Technology
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported