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Search / Trial NCT06490822

The Skin as a Window to the Central Nervous System in Frontotempolar Lombar Degeneration

Launched by NANTES UNIVERSITY HOSPITAL · Jul 1, 2024

Trial Information

Current as of July 26, 2025

Recruiting

Keywords

Ftld Tau Tdp43 Skin Biopsy

ClinConnect Summary

This clinical trial is studying a condition called frontotemporal lobar degeneration (FTLD), which affects behavior and language over time. Researchers think that certain proteins related to FTLD may also show up in the skin, similar to findings in other conditions like Parkinson's disease. By examining skin samples, the goal is to find new ways to diagnose FTLD, especially since there are currently no reliable tests for it.

To participate in this study, you may be eligible if you are between the ages of 50 and 75 and have a diagnosis related to FTLD, such as certain types of language disorders. Healthy volunteers in the same age range can also participate, provided they have no history of neurological diseases or other specific health issues. Participants can expect to undergo a simple skin biopsy, which is a small procedure to take a sample of skin. This trial is currently recruiting participants, and taking part could help advance understanding and diagnosis of FTLD.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria (patients):
  • Adressed or followed at memory clinic or ALS expert center at Nantes university hospital.
  • Aged 50-75 years
  • Fulfilling current diagnosis criteria for one of the disorder: vcfFTD, non-Alzheimer PPA (semantic or non fluent), DCB or PSP,ALS
  • MMSE ≥ 18
  • Membership of social security scheme
  • Inclusion Criteria (healthy volunteers):
  • No history of neurological disease, diabetes, or alteration/damage of peripheral nervous system
  • Aged 50-75 years Paired to at least one patient on age (less or more 5 years)
  • MOCA ≥ 26
  • Membership of social security scheme
  • Non inclusion Criteria (Patients and healthy volunteers):
  • Concomitting conditions affecting the peripheral nervous system such as but not limited to diabetes, renal failure, thyroid disorder, vitamin B12 deficiency, acute and chronic inflammatory diseases HIV, syphilis
  • Know allergy to local anesthetic
  • Known coagulopathy
  • Pregnant women or breastfeeding women
  • Person under court protection sous sauvegarde de justice
  • Person under guardianship
  • Inability to sign an informed consent
  • Non inclusion criteria (Patients) • Patient with neurological disease other than FTLD
  • Non inclusion criteria (Healthy volunteers) :
  • • Evidence of neurological disorder at the inclusion including but not limted to FTLD, Parkinson disease, Alzheimer disease, lewy body dementia, Huntington disease, systemic lupus erythematosus multiple sclerosis; learning disabilities, mental retardation, severe hypoxic brain injuries, brain trauma with permanent cognitive impairments.

About Nantes University Hospital

Nantes University Hospital, a leading academic medical institution in France, is dedicated to advancing healthcare through innovative research and clinical trials. As a prominent sponsor of clinical studies, the hospital integrates cutting-edge scientific exploration with patient care, fostering collaborations among multidisciplinary teams of healthcare professionals and researchers. With a strong emphasis on ethical standards and patient safety, Nantes University Hospital aims to contribute to the development of effective therapies and interventions that enhance patient outcomes and overall public health.

Locations

Nantes, , France

Patients applied

0 patients applied

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported