NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome

Launched by FUJIAN MEDICAL UNIVERSITY UNION HOSPITAL · Jul 1, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating ways to better diagnose Parkinson's disease (PD) and similar conditions known as atypical Parkinsonian syndromes (APS), which include Progressive Supranuclear Palsy (PSP) and Multiple System Atrophy (MSA). The goal is to identify specific markers in the blood that can help doctors distinguish between these conditions, especially in the early stages when symptoms can be confusing. Researchers will use advanced technology to analyze blood samples from patients to see if there are unique patterns that could serve as reliable indicators for these diseases.

To participate in this study, individuals must be between 45 and 80 years old and meet certain diagnostic criteria for PD, MSA, or PSP, as defined by expert guidelines. Participants will undergo blood tests to help researchers gather the necessary data. This trial is currently looking for volunteers, and it is important to note that individuals with hereditary forms of Parkinson's or those who have had specific surgeries may not be eligible. By joining this study, participants could contribute to the development of improved diagnostic methods that may benefit many others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1) MSA and PSP inclusion criteria
• • Age range from 45 to 80 years old;
• • 1. MSA inclusion criteria
• • Age range from 45 to 80 years old;
• • Meets the Chinese expert consensus on the diagnostic criteria for multiple system atrophy (2017) or the International Society for Parkinson\'s Disease and Movement Disorders (MDS) diagnostic criteria for multiple system atrophy (2022)
• • ③ MSA subtype grouping: MSA is divided into MSA-P and MSA-C subtypes based on the severity of initial and/or motor symptoms, with Patients with Parkinson\'s syndrome as the main type are MSA-P, while patients with cerebellar syndrome as the main type are MSA-C.
• • (2) PSP inclusion criteria
• • Age range from 45 to 80 years old;
• • ② PSP patients who meet the diagnostic criteria for progressive supranuclear palsy in China (2016) or the diagnostic criteria for progressive supranuclear palsy in the International Society for Parkinson\'s Disease and Movement Disorders (MDS) (2017)
• • (3) Selection criteria for Parkinson\'s disease case group
• • Age range from 45 to 80 years old;
• • Patients with idiopathic Parkinson\'s disease who meet the diagnostic criteria of the International Committee on Motor Disorders (MDS) for Parkinson\'s disease (2015);
• * Classification criteria for subtypes of Parkinson\'s disease:
• • 1. Tremor predominant type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≥ 1.15
• • 2. PIGD type: According to the MDS-UPDRS score, the ratio of average tremor score to average PIGD score is ≤ 0.9
• Exclusion Criteria:
• • ① Hereditary Parkinson\'s syndrome, secondary Parkinson\'s syndrome.
• • After deep brain stimulation (DBS) surgery.
• • Have a history of malignant tumors.