Effect of Flax in Yogurt on Blood Cyanide Levels

Launched by ST. BONIFACE HOSPITAL · Jul 5, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Effect of Flax in Yogurt on Blood Cyanide Levels," is designed to study how different forms of flaxseed mixed into yogurt might affect blood cyanide levels in healthy adults. Researchers will test whole ground flaxseed, roasted ground flaxseed, whole intact flaxseed, and flaxseed hulls to see how they impact the body. The study will take place at the IH Asper Institute, and while it is not yet recruiting participants, it aims to include adults aged 18 and older who are generally healthy and willing to participate.

To be eligible for this trial, participants should not be pregnant or breastfeeding, should not have any serious medical conditions currently being treated, and should have no recent history of certain health issues, like gastrointestinal disorders or heart problems. Participants can expect to eat yogurt mixed with different types of flaxseed during the study and will need to meet specific health criteria to ensure their safety. This trial will help researchers understand how adding flaxseed to yogurt could affect health, particularly regarding blood cyanide levels.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Generally healthy adult, 18 years or older;
• • 2. Willing to provide informed consent;
• • 3. Willing/able to comply with the requirements of the study.
• Exclusion Criteria:
• • 1. Pregnant or lactating;
• • 2. Medical history of disease that is currently under treatment;
• • 3. Active treatment for any type of cancer within 1 year prior to study start;
• • 4. Presence of a gastrointestinal disorder, daily use of any stomach acid-lowering medications or laxatives (including fibre supplements) within the past month or antibiotic use within the past 6 weeks;
• • 5. Plasma concentration of vitamin B12 \< 148 pmol/L;
• • 6. Complete blood count outside normal range;
• • 7. Medical history of liver disease or liver dysfunction (defined as plasma AST or ALT ≥3 times the upper limit of normal (ULN));
• • 8. Fasting blood glucose ≥6.1 mmol/L and/or HbA1c ≥6.0%;
• • 9. Fasting plasma total cholesterol \>7.8 mmol/L;
• • 10. Fasting plasma HDL \<0.9 mmol/L;
• • 11. Fasting plasma LDL \>5.0 mmol/L;
• • 12. Fasting plasma triglycerides \>2.3 mmol/L;
• • 13. Systolic blood pressure \>140 mmHg or diastolic blood pressure \>90 mmHg;
• • 14. Major surgery within the last 3 months;
• • 15. Smoking, use of tobacco, vape or cannabis (within the last week);
• • 16. Allergies to flaxseed or yogurt;
• • 17. Aversion or unwillingness to eat study foods;
• • 18. Participation in another clinical trial, current or in the past 4 weeks