Light vs. Moderate Intensity Exercise in Individuals With Myasthenia Gravis

Launched by HEALTHPARTNERS INSTITUTE · Jun 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how different levels of exercise—light and moderate intensity—affect the health and well-being of people with Myasthenia Gravis (MG), which is a condition that causes weakness in the muscles. The study will enroll 20 participants who are between 18 and 80 years old and have been stable on their MG medication for at least three months. The participants will take part in a special exercise program at the HealthPartners Neuroscience Center, where they will work with certified exercise professionals. They will exercise in small groups three times a week for 12 weeks, randomly assigned to either the light or moderate exercise group. The researchers hope to find out if light exercise can provide similar benefits as moderate exercise for individuals with MG.

To be eligible for the trial, participants must be able to sign consent forms and cannot have recent experience with regular exercise or certain medical issues that could interfere with their ability to participate. This includes serious heart or lung conditions, significant cognitive impairment, or being pregnant. This study is a great opportunity for those with MG to engage in a supportive exercise program while helping to advance understanding of how exercise can improve health outcomes for people with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ability to provide and provision of signed and dated informed consent form.
• • Age 18-80
• • Diagnosis of generalized MG.
• • On a stable MG prescription medication regimen for the last 3 months.
• Exclusion Criteria:
• • Non-English speaking
• • Regular exercise participation within the month prior to study enrollment or any outside exercise participation during the study intervention period.
• • Significant cognitive impairment of any etiology that would impact study participation.
• • History of heart failure, chronic lung disease, angina or any other condition that causes unreasonable shortness of breath on exertion.
• • History of any serious neurological, psychiatric, or substance use disorders that would impact study participation.
• • Women who are currently pregnant or planning to become pregnant during the study.
• • Any other medical conditions that could affect their ability to participate in exercise for the study duration (as determined by study investigators).
• • Active participation or past participation ≤3 months in any other interventional research study.
• • Unwilling to participate in all study related activities.