Varicocelectomy in Patients With Clinical Varicocele and Unexplained Infertility
Launched by KAFRELSHEIKH UNIVERSITY · Jun 30, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effects of a surgical procedure called varicocelectomy on men who have a condition known as varicocele and are experiencing unexplained infertility. Varicocele is when the veins in the scrotum become enlarged, which can affect sperm quality and male fertility. The main goal of the study is to see if this surgery helps improve pregnancy outcomes for couples trying to conceive, while also looking at improvements in sperm health and hormone levels after the procedure.
Men between the ages of 18 and 45 who have been trying to conceive for at least a year without success may be eligible to participate. They should have a normal semen analysis, which means their sperm count and quality are within healthy ranges, and they must have a clinically diagnosed varicocele. Participants in this trial can expect to undergo the varicocelectomy procedure and will be monitored for their fertility outcomes and improvements in sperm health over time. It's important to note that men with certain health issues or those whose partners have fertility problems will not be eligible for the study.
Gender
MALE
Eligibility criteria
- Inclusion Criteria:
- • Patients unable to conceive after 12 month of regular and unprotected intercourse
- • Male patients aged 18 -45 years old
- • Normal semen analysis (concentration, motility and morphology) according to WHO criteria 2021
- • Infertile men with clinical varicocele (grade II,III) subjected to varicocelectomy
- • No history of other congenital or acquired urogenital diseases
- • Primary infertility
- • Normal BMI (18.5-24..9)
- Exclusion Criteria:
- • History of other congenital or acquired urogenital diseases
- • Age outside inclusion criteria
- • Grade I varicocele confirmed by ultrasound ( subclinical varicocele )
- • Abnormal semen analysis
- • Recurrent varicocele
- • Patient unable or unwilling to comply with follow-up schedule
- • Female fertility issues (anovulation , hormonal infertility, tubal factor, endometriosis)
About Kafrelsheikh University
Kafrelsheikh University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that contribute to the enhancement of healthcare practices and patient outcomes. With a strong emphasis on interdisciplinary collaboration, the university harnesses its diverse expertise in medical sciences, engineering, and technology to conduct rigorous clinical studies. Kafrelsheikh University aims to foster innovation in clinical research, ensuring compliance with ethical standards and regulatory requirements, while actively engaging in community health initiatives to address pressing health challenges. Through its commitment to excellence, the university seeks to develop evidence-based solutions that improve health and well-being at both local and global levels.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Kafr Ash Shaykh, , Egypt
Patients applied
Trial Officials
Ahmed A. Khalifa, MSc
Principal Investigator
Kafrelsheikh University
Tarek M. Abdelbaky, MD
Study Director
Kafrelsheikh University
Ayman S. Rashed, MD
Study Director
October 6 University
Khaled M. Magdy Zeinelabden, MD
Study Director
Kafrelsheikh University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported