Multiparameter Optimized tES for Memory in Aging

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Jun 30, 2024

Keywords

ClinConnect Summary

This clinical trial, titled "Multiparameter Optimized tES for Memory in Aging," is exploring a new way to potentially improve memory in older adults using a technique called transcranial electrical stimulation (tES). This noninvasive method involves applying a gentle electrical current to the brain to see if it can enhance memory functions as people age. The study aims to identify the best ways to use tES, including how much stimulation is needed and where to place the electrodes on the head for the best results.

To participate in this trial, individuals must be between the ages of 50 and 85 and in good health, meaning they should not have any significant mental or physical illnesses. Participants should also be able to read and understand the consent documents and be fluent in English. If you join this study, you can expect to follow a specific schedule and undergo assessments to measure the effects of tES on your memory. It’s important to note that certain conditions, like a history of seizures or certain medications, may prevent someone from being eligible for the study. This trial is currently not recruiting participants, so keep an eye out for updates if you are interested.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 50 - 85 y.o.
• • Endorse good health with no history of mental or physical illness
• • Willingness to adhere to the study schedule and assessments
• • Able to read consent document and provide informed consent.
• • English is a first or primary fluent language.
• Exclusion Criteria:
• • Any current psychiatric diagnosis or current Clinical Global Impression ratings of psychiatric illness \> 1
• • Neurodevelopmental disorders, history of Central Nervous System (CNS) disease, concussion, overnight hospitalization, or other neurologic sequela, tumors, seizures, meningitis, encephalitis, or abnormal CT or MRI of the brain
• • Any psychotropic medication is taken within 5 half-lives of procedure time
• • Any head trauma resulting in loss of consciousness
• • Visual impairment (except the use of glasses)
• • Inability to complete cognitive testing
• • Active participation or plan for enrollment in another evidence-based clinical trial affecting the psychosocial function
• • Repeated abuse or dependence upon drugs (excluding nicotine and caffeine) or taking medications including stimulants, modafinil, thyroid medication, or steroids
• • Implanted devices/ferrous metal of any kind
• • History of seizure or epilepsy, currently taking medications that lower seizure thresholds
• • Claustrophobia or other conditions that would prevent the MRI assessment.
• • Pregnancy (or suspected/possible pregnancy or plan to become pregnant in the short term).
• • Urine Pregnancy Test: If the subject is a woman of childbearing potential and /or a man capable of fathering a child before, during, and/or after participation precautions should be taken. Examples of acceptable methods of birth control for participants involved in the study include birth control pills, patches, Intrauterine Devices (IUD), condoms, sponges, diaphragm with spermicide, or avoiding sexual activity that could cause the subject to become pregnant.
• • Inability to adhere to the treatment schedule.
• • Inability to fit the wearable device to the user's head.