Comparison of the Role of Losartan Alone vs Hydrochlorothiazide Plus Losartan

Launched by RESNTEC, INSTITUTE OF RESEARCH · Jul 1, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how effective the medication losartan is when used alone compared to when it is combined with another medication called hydrochlorothiazide in patients with diabetic nephropathy, a condition that can cause kidney damage. The trial specifically looks at whether this combination treatment can better reduce proteinuria, which is the presence of excess protein in urine and a sign of kidney problems. Losartan is already known to help lower blood pressure and protect the kidneys, but researchers want to see if adding hydrochlorothiazide, a diuretic that helps remove extra fluid from the body, provides additional benefits.

To participate in this trial, individuals need to be at least 18 years old and have proteinuria at the time of screening. They should also have a certain level of kidney function, as measured by creatinine clearance. However, people with very high blood pressure, those with other serious kidney diseases, or individuals who are pregnant or breastfeeding, among other criteria, will not be eligible. The trial is not yet recruiting participants, but once it starts, those who qualify will be able to contribute to important research that may help improve treatment options for kidney-related issues in diabetes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients of both genders with ≥18 years of age.
• • Presence of proteinuria/albuminuria at time of screening.
• • Creatinine clearance of 30 mL/min or higher.
• Exclusion Criteria:
• • A systolic blood pressure of 180 mm Hg or higher, a diastolic blood pressure of 110 mm Hg or higher.
• • Presence of a second primary renal disease in addition to diabetic nephropathy.
• • Patients with type 1 diabetes.
• • A history of a cardiovascular or cerebrovascular event within 3 months before inclusion.
• • Serum potassium of 6.0 mmol/L or higher.
• • Transplantation or immunosuppressive treatment.
• • Contraindication for the use of losartan or hydrochlorothiazide.
• • Pregnancy or lactation.