Clinical Efficacy of Prophylactic Intravenous Neostigmine and Atropine in Preventing Post-Dural Puncture Headache Among Parturient Undergoing Spinal Anesthesia for Cesarean Section: A Double-blind Randomized Placebo-controlled Trial

Launched by MINIA UNIVERSITY · Jun 30, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether a combination of two medications, neostigmine and atropine, given through an intravenous (IV) line can help prevent a common problem called post-dural puncture headache. This type of headache can happen after receiving spinal anesthesia during a cesarean section, which is when a baby is born through surgery. The goal of this research is to find a way to help women avoid this painful headache before it starts, rather than just treating it after it occurs.

To participate in the trial, women must be between 18 and 35 years old, be planning to have an elective cesarean section, and not have certain health issues that could complicate the procedure. Unfortunately, women who are very overweight, have had complications with previous surgeries, or need emergency care won't be able to join. If you decide to participate, you will receive either the study medication or a placebo (a treatment with no active ingredients), and neither you nor the doctors will know which one you received. This is to ensure that the results are fair and unbiased. The trial is not yet recruiting participants, so you will need to wait until they start accepting volunteers.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Parturient ladies
• • Age ranges from 18 to 35 years old.
• • ASA II with elective caesarean section under sub-arachnoid block
• Exclusion Criteria:
• • BMI \>35
• • Refusal to participate
• • surgical complications necessitating a blood transfusion
• • Emergency caesarean section
• • the need for endotracheal intubation or vasopressors
• • any contraindication to regional anesthesia (such as a history of persistent cephalgia, convulsions, cerebrovascular events