Exercise Training in Women With Heart Disease 2

Launched by OTTAWA HEART INSTITUTE RESEARCH CORPORATION · Jul 2, 2024

Keywords

ClinConnect Summary

This clinical trial, called "Exercise Training in Women With Heart Disease 2," is designed to see how two different types of exercise training affect women with coronary heart disease (CHD). Participants will be randomly assigned to either high-intensity interval training (HIIT) or moderate-to-vigorous intensity continuous training (MICT), and they'll engage in exercise sessions twice a week for 12 weeks, all conducted online. The study will evaluate how well these exercises improve participants' physical ability, as well as their overall quality of life and mental health, through various tests and questionnaires.

To be eligible for this trial, women aged 65 to 74 who have experienced certain heart-related events or procedures—like a heart attack or bypass surgery—may qualify, provided they can perform a specific exercise test. However, those currently exercising regularly or with certain heart or lung conditions will not be included. Participants can expect to receive support and guidance during their exercise sessions, and follow-up visits will occur at 12 and 26 weeks to monitor their progress. This trial aims to help improve exercise options and health outcomes for women with heart disease.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Women (i.e., female sex assigned at birth) with CHD (e.g., coronary artery bypass grafting surgery \[CABG\], percutaneous coronary intervention \[PCI\], acute myocardial infarction \[MI\], MI with no obstructive coronary artery disease \[MINOCA\], or ischemia with no obstructive coronary artery disease \[INOCA\] at least 4 weeks post procedure or event; based on clinical evidence this is a safe period of time to exercise);
• • 2. Patient is able to perform a symptom limited CPET (this is the primary outcome and needed to determine peak HR for the exercise training prescription); and
• • 3. Patient is able to read and understand English or French.
• Exclusion Criteria:
• • 1. Patient is currently participating in routine exercise training (\>2x/week, routine exercise training is defined as a planned, structured, and repetitive exercise that is performed in order to maintain or improve physical fitness.) (this may reduce the impact of HIIT or MICT on outcomes);
• • 2. Patient has: NYHA class III-IV heart failure symptoms; unstable angina; or established diagnosis of chronic obstructive pulmonary disease, severe mitral or aortic stenosis, or hypertrophic obstructive cardiomyopathy (this may interfere with the ability to engage in MICT or HIIT);
• • 3. Patient has uncontrolled arrhythmia (this may impact the HR-based exercise training prescription and monitoring);
• • 4. Patient is unable to provide written informed consent; or
• • 5. Patient is unwilling or unable to return for follow-up visits at 12 and 26 weeks.
• • 6. Patient is unwilling to be randomized to HIIT or MICT.