Differential Thrombogenesis by EPA and DHA Mediated by HDL

Launched by THE MIRIAM HOSPITAL · Jul 2, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how two types of omega-3 fatty acids, EPA and DHA, found in fish oil, affect cholesterol levels and blood platelets in people with high cholesterol. The researchers want to find out how safe these supplements are and how they might improve the way our bodies handle fats in the blood.

To participate, individuals need to be aged 25 to 74 and have specific cholesterol levels, including high triglycerides and low HDL (the "good" cholesterol). Participants will visit the clinic five times over the study and will be asked to keep a 28-day record of their food and activity. It's important for those interested to note that they should not be pregnant, breastfeeding, or planning to change their diet or exercise significantly during the study. This trial is not yet recruiting, but if you meet the criteria and are interested, more information will be available soon.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Fasting TG levels ≥ 150 mg/dL and \< 500 mg/dL and HDL-C ≤ 40 (men) or ≤ 50 (women)
• • LDL-C \> 40 mg/dL and ≤ 130 mg/dL
• • Able to provide informed consent and adhere to study schedules
• • Agree to follow and maintain a relatively stable and low fatty fish intake diet (\<3 servings per week)
• Exclusion Criteria:
• • Female with pregnancy, planned pregnancy (within the study period), or currently breastfeeding.
• • Subjects with weight changes greater than 20% over the past 3 months
• • Subjects planning a significant change in diet or exercise levels
• • Malabsorption syndrome and/or chronic diarrhea
• • Use of dietary supplements containing n-3 PUFA fatty acids
• • Frequent consumption of n-3 PUFA-enriched fish (\>3 times a week)
• • Abnormal liver, kidney, or thyroid functions
• • Drug or alcohol abuse within 6 months or significant mental/psychological impairment
• • Current smokers
• • Subjects taking daily aspirin, NSAIDs, anticoagulant, or corticosteroids
• • Subjects with known bleeding disorders (for example, hemophilia)
• • Known sensitivity or allergy to fish, shellfish, or omega-3 fatty acid supplements
• • Subjects requiring regular transfusions for any reason
• • No ethnic/racial groups will be excluded