Effect of Triticum Aestivum on Appetite, Ghrelin, Leptin, Adiponectin Hormonal Axis in Patients With Obesity

Launched by COORDINACIÓN DE INVESTIGACIÓN EN SALUD, MEXICO · Jul 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a natural product called Triticum aestivum, commonly known as wheat, on people who are struggling with obesity. The researchers want to find out if this wheat can help regulate hormones that control appetite and weight, specifically looking at hormones like ghrelin (which stimulates hunger) and leptin (which helps you feel full). The goal is to explore new treatment options for obesity, especially since current methods often don't work well for everyone.

To participate in this trial, you need to be between 30 and 50 years old, live in the Guadalajara area, and have a body mass index (BMI) of 30 or higher, indicating obesity. You must be a stable weight for at least three months and not have certain health issues, like diabetes or serious mental health conditions. If you join the trial, you’ll receive more information about what to expect, including any tests or treatments. It's important to know that this study aims to find better ways to help people manage their weight and improve their overall health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • People of any sex (eumenorrheic women with mechanical or definitive contraceptive method without hormonal treatment).
• • Age from 30 to 50 years old. Residents of the metropolitan area of Guadalajara. Signed informed consent form. People with a diagnosis of obesity (BMI ≥30 - 39.9 kg/m2), stable body weight within the 3 months prior to the start of the study.
• Exclusion Criteria:
• • Diagnosis of diabetes and dyslipidemia. Diagnosis of anxiety and/or depression. History of: liver disease, chronic kidney disease, thyroid disease, cancer. Antidiabetic treatment, lipid-lowering, food supplements, antidepressants, corticosteroids.
• • Acute infectious processes Alcoholism and/or active smoking in any intensity within the 12 months prior to the start of the study.
• • Suspected or confirmed pregnancy or breastfeeding. History of drug intake. Recent surgery (\<3 months) Carrying a pacemaker, or any other bioelectronic or metallic element. Excessive sedentary lifestyle defined as physical activity less than the equivalent of 15 minutes of walking per day.
• • Excessive exercise, defined as physical activity equivalent to running for 60 minutes per day.
• • Intake of anorexigenic drugs, hypolipidemic drugs or drugs with effect on body weight.
• • History of any type of cancer, hyperthyroidism, hypothyroidism, renal disease, liver disease and pancreatic disease.
• • History of hypersensitivity to the study drug (gluten).