Periodontal Initial Treatment Combined With Glucocorticoid Therapy for Erosive Oral Lichen Planus

Launched by SHANGHAI NINTH PEOPLE'S HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIVERSITY · Jul 11, 2024

Keywords

ClinConnect Summary

This clinical trial is looking into a new way to treat erosive oral lichen planus, a condition that causes painful sores in the mouth. The researchers want to see if combining a specific dental treatment, called periodontal initial treatment, with medication known as glucocorticoids (which help reduce inflammation) can be more effective than just using glucocorticoids alone. Participants will have one side of their mouth treated with both therapies under local anesthesia, while the other side will receive the traditional glucocorticoid treatment. Over the course of 12 weeks, doctors will check the size of the sores and the health of the gums to see how well the treatments are working.

To be eligible for this trial, participants should be between 65 and 74 years old and have erosive oral lichen planus that has lasted more than two months. They should also have specific types of mouth sores and signs of gum disease. However, some people are not eligible, including pregnant women, those with certain health conditions, or anyone who has had recent dental work. If you join the study, you'll have regular check-ups to monitor your progress and help researchers understand the safety and effectiveness of this combined treatment approach.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Existence of erosive oral lichen planus that lasts for more than 2 months
• • Erosive lesions are located in the buccal mucosa and gingival buccal sulcus of the bilateral mandibular posterior teeth area
• • The erosive lesions are mild to moderate (single or multiple small area erosions; 3mm ≤ longest diameter ≤ 10mm; 9mm2 ≤ total area of erosions ≤ 100mm2), and the degree of erosion on both sides is similar (the difference in the size of erosion on both sides does not exceed ± 25%)
• • The plaque index in the area of erosive lesions is ≥ 3; Dental calculus index ≥ 2; Gingival index ≥ 2;
• • Accompanied by stage II-IV extensive periodontitis
• Exclusion Criteria:
• • Pregnant women, lactating women, or women planning to conceive during the trial period
• • Patients with coagulation dysfunction or other uncontrolled systemic diseases who cannot undergo periodontal treatment
• • Has undergone basic periodontal treatment within the past 6 months
• • Individuals with a history of allergy to local anesthetic drugs such as articaine
• • Individuals with contraindications to glucocorticoids
• • Patients with lesion area erosion caused by trauma or chemical stimulation
• • Patients with mental disorders who are difficult to cooperate with treatment