Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT

Launched by MAHIDOL UNIVERSITY · Jul 5, 2024

Keywords

ClinConnect Summary

This clinical trial is comparing two treatments for patients who have had an acute ischemic stroke, which is when blood flow to the brain is blocked. The study is looking at two medications: Tenecteplase and Alteplase. Both medications are designed to help dissolve the blood clot causing the stroke, but Tenecteplase might be easier to give and have some advantages over Alteplase. The goal is to see which treatment works better in improving patients' recovery when given in mobile stroke units, which are specialized ambulances equipped to provide advanced care quickly.

To participate in this trial, individuals must be diagnosed with an acute ischemic stroke within 4.5 hours of when their symptoms started and be over 18 years old. They also need to be able to provide consent to join the study and not have any conditions that would prevent them from taking these medications. If someone decides to join, they can expect to receive one of the two medications and be monitored for their recovery. This study is currently recruiting participants, so it’s a great opportunity for those who meet the criteria to contribute to important research that could improve stroke treatment in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Diagnosed as Acute ischemic stroke within 4.5 hr of symptom onset
• • Age \> 18 years old
• • No contraindication for thrombolytic drug
• • Informed consent from patients
• Exclusion Criteria:
• • Diagnosed as Acute ischemic stroke with more than 4.5 hours of symptom onset or uncontained onset
• • Have contraindication for thrombolytic drugs