miRNA in Septic Acute Kidney Injury

Launched by UNIVERSITY HOSPITAL OSTRAVA · Jul 4, 2024

Keywords

ClinConnect Summary

This clinical trial is looking at how certain tiny molecules called microRNAs are related to kidney problems that can happen during severe infections like sepsis. Sepsis is a serious condition that can lead to septic shock and can harm the kidneys, making it harder for them to function properly. The researchers want to find out if these microRNAs can help us understand why kidney injuries occur in sepsis and whether they could be used in the future to diagnose or treat these kidney issues.

To participate in this study, you need to be at least 18 years old and either have been recently diagnosed with sepsis (with or without kidney injury) or be a healthy volunteer without any infections. Unfortunately, individuals under 18, those with severe kidney disease, or those on dialysis are not eligible. If you join the study, you will help researchers learn more about septic acute kidney injury, which could lead to better treatments for this serious condition in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The study group of patients with sepsis with or without acute kidney injury
• • age \> 18 years
• • newly diagnosed sepsis or septic shock with or without acute kidney injury
• • Healthy volunteers
• • no evidence of infection on clinical or laboratory examination
• • age \> 18 years
• • signed informed consent
• Exclusion Criteria:
• • The study group of patients with sepsis with or without acute kidney injury
• • age \< 18 years
• • chronic kidney disease at stage 4 or 5 according to KDIGO recommendations (KDIGO) for chronic kidney disease 2024
• • patients on chronic dialysis treatment, or after renal transplantation
• • Healthy volunteers
• • acute or chronic infection
• • renal disease