Evaluation of the Effect of Intra-ligamentary Injection of Diclofenac Potassium Versus Articaine on Anaesthetic Efficacy in Mandibular Molars With Symptomatic Irreversible Pulpitis.

Launched by CAIRO UNIVERSITY · Jul 8, 2024

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ClinConnect Summary

This clinical trial is studying how effective two different types of injections are in managing pain during root canal treatment for patients with severe tooth pain caused by a condition known as irreversible pulpitis. Specifically, the trial compares the effects of an injection of Diclofenac Potassium, a non-steroidal anti-inflammatory drug (NSAID), with Articaine, a common local anesthetic. The goal is to see which injection provides better pain relief during and after the procedure for patients needing treatment on their lower back teeth (mandibular molars).

To participate in this study, potential candidates must be healthy individuals, aged between 18 and 80, who have sharp pain in their back teeth and meet certain medical criteria. Participants will need to provide written consent and attend follow-up appointments. It’s important to note that those with allergies to anesthetics, pregnant or nursing women, and individuals with certain medical conditions may not be eligible. If you decide to join, you can expect to receive either of the two injections during your treatment and will help researchers understand which method is more effective in reducing pain.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Systemically healthy patient (ASA I or II).
• * Mandibular Posterior teeth with:
• • Preoperative sharp pain, Absence or slight widening in the periodontal ligament (PDL), Vital response of pulp tissue to cold pulp test.
• • patients who agree to provide written consent and the patients able to understand the pain scale and attend for recall appointments
• Exclusion Criteria:
• • 1. Patients allergic to anesthetic solutions \& other NSAIDs.
• • 2. Pregnant or nursing females.
• • 3. Patients having significant systemic disorder (ASA III or IV).
• • 4. Gastrointestinal disorders.
• • 5. If the initial diagnosis revealed pain in more than one tooth.
• • 6. Hemostatic disorders or anti-coagulant therapy during the last month.
• • 7. Consumption of opioid or non-opioid analgesics or NSAIDs during the last 12 hours before treatment.
• 8. Teeth that have:
• • i. Periodontal involvement (with pocket depth greater than 5mm, associated with swelling or fistulous tract, or greater than grade I mobility).
• • ii. No possible restorability. iii.Signs of pulpal necrosis; associated sinus tract or swelling.
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