Effects of Vagus Nerve Pulmonary Branch Block on Postoperative Cough After VATS Lung Resection

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Jul 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying whether a specific procedure called vagus nerve pulmonary branch block can help reduce coughing after lung surgeries known as VATS (Video-Assisted Thoracoscopic Surgery). Postoperative cough is a common issue that can make recovery harder and affect the quality of life for patients. In this trial, 104 patients who are having lung resections will be randomly assigned to either receive the nerve block or be in a control group. Researchers will look at how many patients experience coughing three weeks after their surgery, along with other factors like hoarseness and breathing ability.

To be eligible for this trial, participants should be between 18 and 70 years old, have a body mass index (BMI) between 18 and 30, and be in relatively good health according to specific medical guidelines. Patients who have had previous lung surgeries, certain chronic cough conditions, or other specific health issues may not qualify. Those who join the study will have the chance to help researchers understand if this nerve block can improve recovery after lung surgery, contributing valuable information to future treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age between 18 and 70 years old.
• • BMI between 18 and 30 kilograms per square meter (kg/m²).
• • ASA Physical Status Classification of I, II, or III.
• • Preoperative pulmonary imaging demonstrating peripheral lesions, with clinical staging T≤2, N≤1, M0.
• • Undergone thoracoscopic lung resection surgery.
• • Patients managed by the same lead surgeon's team.
• • Obtained informed consent, with patients agreeing and signing the informed consent document.
• Exclusion Criteria:
• • Patients with a history of chemotherapy or previous pulmonary surgery.
• • Presence of chronic cough due to respiratory infectious diseases, pharyngitis, rhinitis, COPD, asthma, post-nasal drip syndrome, etc.
• • Individuals exhibiting ECG abnormalities such as atrial fibrillation, bundle branch block, frequent ventricular premature beats, pre-excitation syndrome, etc.
• • Currently using ACE inhibitor medications.
• • Presence of preoperative hoarseness.