Dexmedetomidine Infusion and Postoperative Lung Aeration After Thoracic Surgery

Launched by BRIGHAM AND WOMEN'S HOSPITAL · Jul 13, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring the effects of a medication called dexmedetomidine on lung function after patients undergo thoracic surgery, which involves procedures on the lungs or chest area. The trial involves two groups: one group will receive dexmedetomidine while the other group will receive a placebo, which is a harmless saline solution. The goal is to see if the specific way dexmedetomidine is given can help improve lung aeration—essentially, how well the lungs can fill with air and function after surgery.

To participate in this trial, patients need to be adults aged between 18 and 80 who are scheduled for certain types of lung surgeries, like lobectomy or segmentectomy. However, if someone has urgent surgical needs, certain heart conditions, liver or kidney disease, or is not fluent in English, they may not be eligible. Participants can expect to receive either the medication or the placebo during their surgery, and the study aims to ensure that the way dexmedetomidine is administered is followed consistently. This trial is currently recruiting participants, and it aims to improve how anesthesia is given during lung surgeries to enhance recovery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Adult patients (Age \>18 years until 80 years) undergoing lobectomy and/or segmentectomy.
• Exclusion Criteria:
• • Urgent or emergency thoracic surgery.
• • Other concomitant non-pulmonary procedures (pleurectomy, diaphragmatic procedures, pericardiocentesis, esophageal procedures, thymectomy).
• • Prior lung resection surgery.
• • Epidural block for intraoperative or postoperative analgesia.
• • Preoperative arrhythmia (second degree AV block or pacemaker) or significant bradycardia (heart rate \< 50).
• • Preoperative hypotension (mean arterial blood pressure \< 65 mmHg).
• • Severe functional liver or kidney disease.
• • Non-English speakers
• • Consent withdrawal.