Bile Acids and Microbiome in Early Colorectal Carcinogenesis

Launched by VILNIUS UNIVERSITY · Jul 8, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how changes in bile acids and gut bacteria (microbiome) may play a role in the development of colorectal cancer (cancer in the colon or rectum) and its earlier stages, such as adenomas (polyps). Researchers believe that by understanding these changes, they can identify new ways to diagnose and possibly prevent colorectal cancer. The trial will include adults who are scheduled for a colonoscopy, with some participants having small or large adenomas, invasive colorectal cancer, and others who are healthy.

To participate, you must be an adult referred for a colonoscopy and not have certain conditions, such as pregnancy or a history of colorectal diseases. If you join the study, you will provide samples of your stool, urine, and blood, which will be analyzed for changes in bile acids and gut bacteria. You will also undergo procedures to remove any polyps found during the colonoscopy. This research could lead to important discoveries about colorectal cancer and help improve future diagnostic tests.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Patients that have clinical indications for colonoscopy
• Exclusion Criteria:
• • Pregnancy
• • Immunocompromised
• • Previously diagnosed colorectal diseases
• • Radiotherapy to the pelvis
• • Long term antibiotic use within 6 months
• • Continuous use of proton pump inhibitors