Role of Specific microRNAs in Cluster Headache

Launched by IRCCS NATIONAL NEUROLOGICAL INSTITUTE "C. MONDINO" FOUNDATION · Jul 9, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating the role of specific microRNAs (small molecules that help regulate gene expression) in cluster headaches, a severe type of headache that can occur in episodes. Researchers want to understand how these microRNAs, along with certain neuropeptides (substances that can trigger headache attacks), are involved in causing cluster headaches. They will be looking at blood samples from people with chronic and episodic cluster headaches, as well as healthy individuals, to see if there are any differences in the levels of these molecules.

To participate in this study, you must be between 18 and 65 years old and meet specific criteria based on your headache type. For example, individuals with episodic cluster headaches should have been diagnosed with this condition for at least a year. Participants can expect to provide blood samples and may be asked questions about their health. This study is important because it aims to shed light on the biological factors that contribute to cluster headaches, which could lead to better treatments in the future.

Gender

ALL

Eligibility criteria

• • - Healthy Controls
• Inclusion Criteria:
• • age between \>18 and \<65 years
• Exclusion Criteria:
• • diagnosis of primary and/or secondary headache according to ICHD-III criteria (only diagnosis of sporadic tension type headache is allowed)
• • diagnosis of neurological disorders
• • diagnosis of medical conditions considered clinically relevant by the researcher
• • pregnant and lactating women
• • taking NSAIDs, triptans or opiates in the previous 24 hours
• • Episodic Cluster Headache
• Inclusion Criteria:
• • diagnosis of Episodic Cluster Headache according to ICHD-III criteria (at least 1 year at screening)
• • age between \>18 and \<65 years of both genders
• Exclusion Criteria:
• • concomitant diagnosis of other primary and/or secondary headache according to ICHD-III criteria (only diagnosis of sporadic tension headache is allowed)
• • diagnosis of other neurological disorders
• • diagnosis of medical conditions considered clinically relevant by the researcher
• • diagnosis of chronic pain syndrome of any nature
• • pregnant and lactating women
• • use of substances of abuse
• • Chronic Cluster Headache
• Inclusion Criteria:
• • diagnosis of Chronic Cluster Headache according to ICHD-III criteria (at least 1 year at screening)
• • age between \>18 and \<65 years of both genders
• Exclusion Criteria:
• • concomitant diagnosis of other primary and/or secondary headache according to ICHD-III criteria (only diagnosis of sporadic tension headache is allowed)
• • diagnosis of other neurological disorders
• • diagnosis of medical conditions considered clinically relevant by the researcher
• • diagnosis of chronic pain syndrome of any nature
• • pregnant and lactating women
• • use of substances of abuse