Night Owl Metabolism

Launched by JOHNS HOPKINS UNIVERSITY · Jul 12, 2024

Keywords

ClinConnect Summary

The Night Owl Metabolism clinical trial is studying how the timing of meals affects blood sugar levels in young people aged 17 to 23 who are overweight or have prediabetes. The researchers want to find out if having a glucose test (a test that measures how well your body processes sugar) at a time that matches a person's natural sleep patterns (their chronotype) can improve how their body handles sugar and insulin. Participants will take the glucose test twice: once at a time that suits their body clock and once at a mismatched time. They will also have two meals at aligned and misaligned times while wearing a device that tracks their blood sugar continuously.

To join this study, participants need to be overweight but not severely so, get enough sleep (more than 7 hours a night), and have a consistent sleep schedule during the week and weekend. They cannot have diabetes, sleep disorders, or other serious health issues. If eligible, participants can expect to take part in various tests and meals while being closely monitored. This study is currently recruiting participants, and it aims to help understand how meal timing influences health in young people.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Overweight similar to (BMI ≥ 85th percentile but \<95th percentile for age and sex per Centers for Disease Control and Prevention growth curves (as Centers for Disease Control and Prevention growth curves contain ages ≤ 20y; if ages 21-23 years, the BMI ≥ 85th and \<95th percentile equivalents for a 20-year-old will be used))
• • Post-pubertal
• • Normal sleep duration (avg. \>7 hours of sleep per night)
• • Social jetlag (difference between weekend and weekday sleep) of \< 2 hours.
• Exclusion Criteria:
• • Known diabetes, sleep disorders, major organ system illness, pregnancy, or genetic syndrome
• • Medication use known to affect insulin sensitivity, glucose tolerance, or circadian rhythm
• • Screening high risk for obstructive sleep apnea
• • Night shift work.