Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension.

Launched by GENERAL HOSPITAL OF NINGXIA MEDICAL UNIVERSITY · Jul 14, 2024

Keywords

ClinConnect Summary

This clinical trial is looking into how two medications, norepinephrine and phenylephrine, can help manage low blood pressure (hypotension) during spinal anesthesia in women having a cesarean section. The study will compare using these medications as a preventive measure before low blood pressure occurs (prophylactic) versus giving them after blood pressure drops (rescue strategy). The goal is to see how these treatments affect the baby's health, specifically looking at the pH levels in the umbilical artery.

The trial is open to women aged 18 to 45 who are either having their first baby or have had children before, and are at least 37 weeks pregnant with a single baby. To participate, women should be scheduled for a cesarean section and have a certain level of health, as defined by the American Society of Anesthesiologists. However, women who are very short, overweight, have certain health issues like high blood pressure, or have complications with the baby are not eligible to join. If you qualify and choose to participate, you can expect to help researchers find better ways to manage blood pressure during surgery, which could improve outcomes for mothers and their babies.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 18-45 years
• • Primipara or multipara
• • Singleton pregnancy ≥37 weeks
• • American Society of Anesthesiologists physical status classification II
• • Scheduled for cesarean section under spinal anesthesia
• Exclusion Criteria:
• • Body height \< 150 cm
• • Body weight \> 100 kg or body mass index (BMI) ≥ 40 kg/m2
• • Eclampsia or chronic hypertension or baseline blood pressure ≥140 mmHg
• • Hemoglobin \< 7g/dl
• • Fetal distress, or known fetal developmental anomaly