A Study Investigating the Efficacy and Safety of Intravitreal (IVT) Injections of ANX007 in Participants With Geographic Atrophy (GA)
Launched by ANNEXON, INC. · Jul 15, 2024
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a new treatment for a condition called geographic atrophy (GA), which is a type of vision loss that can occur in people with age-related macular degeneration (AMD). The researchers want to find out if monthly injections of a drug called ANX007 can help slow down or reduce vision loss for people with this condition. The trial is currently recruiting participants aged 18 and older, regardless of gender, who have been diagnosed with GA due to AMD.
To join the study, participants need to have a specific diagnosis of GA confirmed by a qualified doctor. Unfortunately, people with GA caused by other eye conditions, like Stargardt disease or certain types of maculopathy, won't be able to participate. If you decide to take part in this trial, you'll receive the injections each month and be closely monitored by the research team to assess how well the treatment is working and to ensure your safety throughout the study.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Diagnosis of GA of the macula secondary to AMD as determined by the Investigator and confirmed by the independent Central Reading Center.
- Exclusion Criteria:
- • Geographic atrophy due to other causes than AMD such as Stargardt disease, cone-rod dystrophy, pathologic myopia, or toxic maculopathies (for example, plaquenil maculopathy) in either eye.
- • NOTE: Other protocol-defined inclusion and exclusion criteria may apply.
About Annexon, Inc.
Annexon, Inc. is a clinical-stage biopharmaceutical company focused on developing innovative therapies for neurodegenerative diseases and autoimmune disorders. Leveraging its proprietary platform that targets the complement system and associated pathways, Annexon aims to address critical unmet medical needs by advancing novel treatments that promote neuronal health and restore immune balance. With a commitment to scientific excellence and patient-centric research, the company is poised to deliver transformative solutions in the field of neurology and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Boston, Massachusetts, United States
Cleveland, Ohio, United States
Zaragoza, , Spain
Beverly Hills, California, United States
Austin, Texas, United States
Salt Lake City, Utah, United States
Chevy Chase, Maryland, United States
Dallas, Texas, United States
Fort Myers, Florida, United States
Stuart, Florida, United States
Sevilla, , Spain
Walnut Creek, California, United States
Lexington, Kentucky, United States
Santa Ana, California, United States
Springfield, Illinois, United States
Barcelona, , Spain
Mountain View, California, United States
Zaragoza, , Spain
Abilene, Texas, United States
Kingston, Pennsylvania, United States
London, , United Kingdom
Cleveland, Ohio, United States
Edmonton, Alberta, Canada
West Des Moines, Iowa, United States
London, Ontario, Canada
Hauppauge, New York, United States
Milano, , Italy
Plantation, Florida, United States
Saint Petersburg, Florida, United States
Reno, Nevada, United States
Edmond, Oklahoma, United States
Amarillo, Texas, United States
Majadahonda, , Spain
Hagerstown, Maryland, United States
Poway, California, United States
Sydney, New South Wales, Australia
'Aiea, Hawaii, United States
Glendale, California, United States
Calgary, Alberta, Canada
Linz, , Austria
Willow Park, Texas, United States
Marietta, Georgia, United States
Portland, Maine, United States
Lynchburg, Virginia, United States
Sacramento, California, United States
Budapest, , Hungary
Sydney, New South Wales, Australia
Mountain View, California, United States
Bellaire, Texas, United States
Oak Park, Illinois, United States
Orlando, Florida, United States
Hagerstown, Maryland, United States
Parramatta, New South Wales, Australia
Praha 10, , Czechia
Fort Worth, Texas, United States
Deerfield Beach, Florida, United States
Hagerstown, Maryland, United States
Springfield, Massachusetts, United States
Albury, New South Wales, Australia
Fort Worth, Texas, United States
Tulsa, Oklahoma, United States
Budapest, , Hungary
Cleveland, Ohio, United States
Tallahassee, Florida, United States
Bloomfield, New Jersey, United States
The Woodlands, Texas, United States
Eugene, Oregon, United States
Austin, Texas, United States
Colorado Springs, Colorado, United States
Austin, Texas, United States
Charleston, South Carolina, United States
Albuquerque, New Mexico, United States
Springfield, Oregon, United States
Erie, Pennsylvania, United States
Ottawa, Ontario, Canada
Katy, Texas, United States
Sacramento, California, United States
Cherry Hill, New Jersey, United States
Te Aro, Wellington, New Zealand
Springfield, Massachusetts, United States
Erie, Pennsylvania, United States
Wake Forest, North Carolina, United States
Sarasota, Florida, United States
Saint Louis Park, Minnesota, United States
Hagerstown, Maryland, United States
Scottsdale, Arizona, United States
Wausau, Wisconsin, United States
Walnut Creek, California, United States
Sarasota, Florida, United States
Asheville, North Carolina, United States
Abilene, Texas, United States
Bellaire, Texas, United States
The Woodlands, Texas, United States
Scottsdale, Arizona, United States
Jacksonville, Florida, United States
Orlando, Florida, United States
Sarasota, Florida, United States
West Des Moines, Iowa, United States
Cherry Hill, New Jersey, United States
Hauppauge, New York, United States
Edmond, Oklahoma, United States
Portland, Oregon, United States
Bellaire, Texas, United States
Dallas, Texas, United States
San Antonio, Texas, United States
San Antonio, Texas, United States
Fullerton, California, United States
Modesto, California, United States
Jacksonville, Florida, United States
Elmhurst, Illinois, United States
Portland, Oregon, United States
Arlington, Texas, United States
Schertz, Texas, United States
Torrance, California, United States
Denver, Colorado, United States
Santa Barbara, California, United States
New York, New York, United States
Portland, Oregon, United States
Aiken, South Carolina, United States
Beaufort, South Carolina, United States
Nashville, Texas, United States
Toronto, Ontario, Canada
Melbourne, New South Wales, Australia
Christchurch, Canterbury, New Zealand
Manchester, Connecticut, United States
Winston Salem, North Carolina, United States
Valencia, Burjasso, Spain
London, , United Kingdom
West Jordan, Utah, United States
Praha 5, , Czechia
Neubrandenburg, Mecklenburg Vorpommern, Germany
Tübingen, , Germany
Pecs, , Hungary
Bydgoszcz, , Poland
Olsztyn, , Poland
Barcelona, , Spain
Cordoba, , Spain
Denver, Colorado, United States
Creteil, , France
Dijon Cedex, , France
Muenster, North Rhine Westphalia, Germany
Tilburg, , Netherlands
Tarnowskie Góry, , Poland
Warsaw, , Poland
Patients applied
Trial Officials
Clinical Trials
Study Director
Annexon, Inc.
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported