NOrthwestern Tempus AI-enaBLed Electrocardiography (NOTABLE) Trial

Launched by NORTHWESTERN UNIVERSITY · Jul 16, 2024

Keywords

ClinConnect Summary

The NOTABLE Trial is a clinical study that aims to find out if an advanced computer program, using artificial intelligence (AI), can help doctors identify heart problems that may not have been diagnosed yet, particularly conditions like atrial fibrillation (an irregular heartbeat) and structural heart disease (issues with the heart's structure). The trial will compare two groups of healthcare providers: one group will receive AI-generated results from heart tests (called electrocardiograms, or ECGs), while the other group will not. This will help researchers understand if the AI tool can improve the detection of these heart conditions and enhance patient care.

To participate in this trial, healthcare providers must meet certain criteria. For example, they should be treating patients who are 65 years or older for atrial fibrillation or patients who are 40 years or older for structural heart disease, and the ECG must be part of regular clinical care. Throughout the trial, providers will assess their patients' risk based on the AI results and decide if further tests are needed. It’s important to note that the trial is not yet recruiting participants, but it offers a chance to explore innovative ways to improve heart health detection and management.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Atrial fibrillation algorithm
• • 1. Age 65 or over
• • 2. ECG obtained as part of routine clinical care
• • 2. Structural heart disease algorithm
• • 1. Age 40 or over
• • 2. ECG obtained as part of routine clinical care
• Exclusion Criteria:
• • 1. Atrial fibrillation algorithm
• • 1. No history of AF
• • 2. No permanent pacemaker (PPM) or implantable cardioverter defibrillator (ICD)
• • 3. No recent cardiac surgery (within the preceding 30 days)
• • 2. Structural heart disease algorithm
• • 1. No history of SHD
• • 2. No echocardiogram within the past 1 year