10 Vs.15 mcg Norepinephrine Bolus in Severe Maternal Hypotension During Cesarean Delivery

Launched by CAIRO UNIVERSITY · Jul 16, 2024

Keywords

ClinConnect Summary

This clinical trial is studying the use of different doses of a medication called norepinephrine to help manage low blood pressure (hypotension) in women undergoing cesarean delivery with spinal anesthesia. Specifically, the researchers want to find out if giving a higher dose of 15 micrograms (mcg) of norepinephrine is more effective than a lower dose of 10 mcg in treating severe cases of low blood pressure during surgery. The goal is to improve the success rate of managing this condition, which can occur during cesarean deliveries.

To participate in the study, women must be full-term pregnant with a single baby and scheduled for an elective cesarean section. They should also be classified as having a low to moderate risk for anesthesia complications. Unfortunately, women with certain heart problems, high blood pressure disorders during pregnancy, or other serious health issues will not be eligible to join. Participants in the trial can expect to receive either the 10 mcg or 15 mcg dose of norepinephrine during their procedure, and their health will be monitored closely to see how well the treatment works. This study aims to improve care for future patients undergoing similar surgeries.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • full-term singleton pregnant women
• • American society of anesthesiologist II, scheduled for elective cesarean delivery,
• Exclusion Criteria:
• • Patients with uncontrolled cardiac morbidities (patients with tight valvular lesion, impaired contractility with ejection fraction \< 50%, heart block, and arrhythmias),
• • hypertensive disorders of pregnancy,
• • peripartum bleeding,
• • coagulation disorders (patients with INR \>1.4 and or platelet count \< 80000 /dL) or any contraindication to regional anesthesia,
• • baseline systolic blood pressure (SBP) \< 100 mmHg