Pathogenesis of Postoperative Infections and Biomarkers for Early Diagnosis of it

Launched by NATIONAL CANCER CENTER AFFILIATE OF VILNIUS UNIVERSITY HOSPITAL SANTAROS KLINIKOS · Jul 17, 2024

Keywords

ClinConnect Summary

This clinical trial is investigating how infections can develop after major abdominal surgeries, particularly focusing on understanding if germs from other parts of the body, like the gut or mouth, might contribute to these infections. The researchers want to analyze samples from patients before their surgery to see if there are specific germs present that later show up at the infection site. Additionally, they are looking into certain biological markers that could help predict if a patient will develop an infection after their surgery.

To be eligible for this study, participants must be at least 18 years old and scheduled for a major abdominal surgery to treat cancer in areas such as the esophagus, stomach, or colon. They should also be willing to take part in the trial. However, those who are pregnant, have undergone certain previous surgeries, or have specific gastrointestinal conditions will not be eligible. If you join this study, you can expect to provide samples before your surgery and help contribute to important research that could improve outcomes for future patients facing similar procedures.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The patient is scheduled to undergo a major resection-type abdominal surgery due to cancer of the esophagus, stomach, pancreas, liver, bile ducts, colon or rectum.
• • 2. Patient is willing to participate.
• • 3. Age ≥ 18 years.
• Exclusion Criteria:
• • 1. Pregnancy.
• • 2. Previous surgical resection of the digestive tract, excluding appendectomy and/or cholecystectomy.
• • 3. Anticipated operation with preventive ileostomy.
• • 4. The operation is planned to be performed as a matter of urgency.
• • 5. Antibiotic therapy ≤1 month. before surgery.
• • 6. Chronic inflammatory bowel disease (non-specific ulcerative colitis, Crohn's disease) or radiation or other colitis of origin.
• • 7. During the last year, the patient suffered from Cl. difficile colitis or was Cl. difficile carrier, had salmonellosis or others intestinal infections.
• • 8. During the last year, the patient used (\> 3 months) pre-/pro-/(syn)biotics.
• • 9. During the last year, the patient has been taking proton pump inhibitors continuously (\> 6 months).