Exercise as Maintenance Therapy in Advanced Lung Cancer

Launched by INDIANA UNIVERSITY · Jul 16, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring how a special exercise program can help people with advanced lung cancer live better and longer. The study focuses on patients with a specific type of lung cancer called non-small cell lung cancer (NSCLC) who are currently receiving maintenance immunotherapy, which is a type of treatment that helps keep the cancer from growing after it has stabilized. By participating in this trial, patients will engage in a supervised home-based exercise program designed to improve their overall health and quality of life.

To be eligible for the study, participants need to be at least 18 years old and diagnosed with either locally advanced or metastatic NSCLC. They should have been on immunotherapy for at least one month and plan to continue it for at least three more months. Additionally, they must be willing and able to participate in the exercise program, which requires internet access and the ability to follow along with virtual sessions. This trial does not include patients who are already exercising regularly or have certain medical conditions that might prevent safe participation. If you're interested in improving your health while managing lung cancer, this study could be a great opportunity to consider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years
• • 2. Known diagnosis of locally advanced (stage III) or metastatic NSCLC
• • 3. Patient is currently receiving maintenance immunotherapy for at least 1 month and planned for at least 3 additional months of therapy
• • 1. Patients receiving maintenance therapy refers to patients with stable disease or partial response to therapy, including patients who have had a history of disease progression but are currently stable or responding to a different therapy
• • 2. Patients previously receiving chemotherapy are eligible as long as at least one month has elapsed since completing chemotherapy. Those currently receiving chemotherapy are not eligible.
• • 4. Patient is willing and able to participate in a supervised home-based exercise program as determined by the MOVE program
• • a.Participants must have internet access and equipment to participate in virtual exercise
• • 5. ECOG performance status of 0-2
• Exclusion Criteria:
• • 1. Already meeting exercise guidelines and participating in at least 150 minutes of moderate or vigorous exercise per IPAQ
• • 2. Unable to participate in the supervised home-based exercise program as determined by the MOVE program
• 3. Medical co-morbidities that preclude patient from participating in supervised exercise, including but not limited to:
• • Advanced heart failure
• • Advanced respiratory disease requiring home oxygen use
• • Uncontrolled psychiatric disorders
• • History of fragility fracture