Efficacy of Topical Tranexamic Acid in Reducing Blood Loss During CS in Patients With Placenta Previa

Launched by CAIRO UNIVERSITY · Jul 17, 2024

Keywords

ClinConnect Summary

This clinical trial is studying how effective a medication called tranexamic acid is at reducing blood loss during cesarean deliveries in women with a condition known as placenta previa, where the placenta is positioned low in the uterus and can cause complications during delivery. The trial will involve two groups of participants: one group will receive tranexamic acid applied directly to the area where the placenta was attached after it is delivered, along with an intravenous (IV) dose, while the other group will only receive the IV dose.

To participate in this trial, women must be between 20 and 40 years old, have a healthy weight, be carrying a single baby, and have been diagnosed with placenta previa through an ultrasound. They should also be at least 36 weeks pregnant. Unfortunately, women with certain health issues, such as diabetes, bleeding disorders, or those on blood-thinning medications, cannot take part in this study. Participants can expect to receive treatment during their cesarean delivery and will help researchers understand if the additional application of tranexamic acid can help lessen blood loss in this situation.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Age: 20-40 years old.
• • BMI less than 30 kg/m2.
• • Pregnancy of singleton living fetus.
• • Placenta previa by ultrasound assessment
• • Gestational age \> 36 weeks.
• Exclusion Criteria:
• • Women with a history of any medical disorder with pregnancy, e.g., Gestational diabetes and hypertension.
• • Women with systemic diseases, e.g., diabetes mellites, systemic immune disorders such as systemic lupus erythematosus
• • Women with bleeding tendency or coagulopathy.
• • Women on anticoagulants or hemodynamically unstable women.
• • Women with uterine abnormalities, such as fibroids or polyps.
• • Emergency termination of pregnancy.
• • Intrauterine fetal death.
• • Pregnancy with obstetric hemorrhage, e.g., antepartum hemorrhage
• • Cases of placenta accrete spectrum disorder or placental abruption
• • Women with known allergies to Tranexamic acid