Characterizing the Inflammation Around Dental Implants: Bacterial Infection, Hypersensitivity or Both?

Launched by MCGILL UNIVERSITY HEALTH CENTRE/RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE · Jul 19, 2024

Keywords

ClinConnect Summary

This clinical trial is exploring why some people experience inflammation around their dental implants, which are metal posts placed in the jaw to support artificial teeth. The researchers want to find out whether this inflammation is caused by bacterial infections, an unusual sensitivity to the implant, or a combination of both. Even though dental implants are generally successful, understanding the reasons behind this inflammation can help improve care for patients who face complications.

To participate in this study, individuals must be between 65 and 74 years old and have at least one functioning dental implant that has been restored with a prosthesis (the artificial tooth). Participants should not have received treatment for gum inflammation around their implant in the last three months. However, those with certain health issues, pregnant women, or individuals undergoing specific dental treatments may not be eligible. If you join the trial, you can expect to undergo assessments to better understand your dental implant's condition and contribute to valuable research that aims to enhance treatment options for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Received at least one functional implant (implant restored with a prothesis);
• • Did not receive peri-implant mucositis and peri-implantitis treatment in the past three months.
• Exclusion criteria:
• • Dental records with incomplete information;
• • Individuals with a weak immune system or chronic disease such as diabetes, heart, lung or kidney disease;
• • Pregnant women;
• • Individuals undergoing orthodontic therapy and those who have oral piercing.
• • History of diseases that modify or suppress the immune and inflammatory response, including rheumatoid arthritis, diabetes, lupus, and inflammatory bowel disease and metastatic cancer;
• • Taking medications that cause antiresorptive osteonecrosis of the jaw (including any dose of intravenous bisphosphonates, oral bisphosphonate intake for more than three years, receptor activator of nuclear factor kappa-B ligand inhibitors, or antiangiogenic medications);
• • Taking medications known to induce gingival hyperplasia including anticonvulsants, immunosuppressants, or calcium channel blockers;
• • Taking steroid medications, systemic or local antibiotics in the last three months (as this may affect the interleukins activity);
• • Received radiation therapy to the head and neck or chemotherapy;
• • Received treatment to manage an inflamed implant, including management of peri-implantitis and peri-implant mucositis in the last three months.