Development of Novel Imaging and Molecular Biomarkers of Fibrosis in Patient With Ulcerative Colitis

Launched by IRCCS SAN RAFFAELE · Jul 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying new ways to see and measure fibrosis in patients with ulcerative colitis, a condition that causes inflammation in the colon. Researchers will use special ultrasound techniques to look at the intestines and compare these images with tissue samples taken during routine colonoscopies. The goal is to develop better imaging tools and markers that can help doctors understand and manage fibrosis in ulcerative colitis patients.

To participate in the study, you need to be an adult (18 years or older) and have had a diagnosis of ulcerative colitis for at least three months. You must also be scheduled for a colonoscopy. Unfortunately, if you are pregnant, have certain infections, or have conditions that would prevent you from having a colonoscopy, you may not be eligible. If you join the study, you can expect to undergo an intestinal ultrasound and provide consent for your participation as part of the standard care process. This research could lead to improved ways of tracking and treating fibrosis in ulcerative colitis in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adult, 18 years of age and older,
• • Established diagnosis (\> three months) of ulcerative colitis,
• • Performing colonoscopy, according to current standards of care and ECCO guidelines,
• • Ability to understand and comply with the study procedure and sign an informed consent form
• Exclusion Criteria:
• • Pregnancy,
• • presence of ascites, active infections, any contraindication to colonoscopy (e.g. intolerance to preparation, severe flare),
• • inability to undergo intestinal ultrasound within the time set by the study,
• • poor quality of ultrasound imaging (due to luminal gas or body habitus), or a diagnosis of malignancy in the pathological specimen.
• • subjects who needs to change therapy