Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder

Launched by UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · Jul 18, 2024

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment method called Low-Intensity Focused Ultrasound (LIFU) to see how it affects brain activity in people with Alcohol Use Disorder (AUD). The goal is to understand if this technique can help those struggling with alcohol use. The trial is currently looking for participants aged 18 and older, who have been diagnosed with AUD and are willing to undergo a brain MRI as part of the study.

If you choose to participate, you will be closely monitored throughout the trial, and you'll need to follow the study's guidelines. However, some individuals may not qualify for the study, including those who are pregnant or breastfeeding, have serious mental health issues, or have certain medical conditions. This trial is an opportunity to explore a potential new approach to treating AUD, and participants will contribute to important research that could help others in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female ≥ 18 years of age.
• • 2. Documentation of an AUD diagnosis per DSM-5 criteria as evidenced by problematic pattern of alcohol use leading to clinically significant impairment or distress, as manifested by at least two of the DSM-5 criteria, occurring within a 12-month period.
• • 3. Be willing to undergo a brain MRI and follow study protocol.
• Exclusion Criteria:
• • 1. Pregnant or breastfeeding.
• • 2. Presence of a condition or abnormality that would compromise the safety of the patient or the quality of the data.
• • 3. Non-English speaking.
• • 4. Other investigational AUD treatments.
• • 5. Primary psychosis, Bipolar I, or severe personality disorder.
• • 6. Active suicidality or history of suicide attempt in the past 5 years.
• • 7. Cognitive impairment (MoCA \<24)
• • 8. Significant medical or neurological disease, or life expectancy \<12 mos.
• • 9. Significant brain abnormality on brain imaging.
• • 10. Any MRI exclusion criteria.